Skip to main content



Professor Li-Kwan Chang

Professor Li-Kwan Chang

Li-Kwan Chang

Title Professor
Education Ph.D., Graduate Institute of Basic Medical Science, Chang Gung University
Research Expertise Molecular Virology, Microbiology, Molecular Biology
LAB Molecular Virology Lab. (EM-2F)
TEL +886-2-3366-4520
Personal webpage  



  1. Lin LT, Lu YS, Huang HH, Chen H, Hsu SW, Chang LK*. Regulation of Epstein-Barr virus minor capsid protein BORF1 by TRIM5α. Int J Mol Sci. 2022 Dec 5;23(23):15340 (*Correspondence)
  2. Chang CH, Lee YC, Hsiao G, Chang LK, Chi WC, Cheng YC, Huang SJ, Wang TC, Lu YS, Lee TH. Anti-Epstein–Barr viral agents from the medicinal herb-derived fungus Alternaria alstroemeriae Km2286. J Nat Prod. 2022 Nov 25;85 (11), 2667-2674.
  3. Hwang SP, Huang LC, Wang WH, Lin MH, Kuo CW, Huang HH, Chang LK*. Expression of Rta in B Lymphocytes during Epstein-Barr Virus Latency. J Mol Biol. 2020 Sep 4;432(19):5227-5243. (*Correspondence)
  4. Huang HH, Wang WH, Feng TH, Chang LK* (2020) Rta is an Epstein-Barr virus tegument protein that improves the stability of capsid protein BORF1. Biochem Biophys Res Commun. 2020 Mar 12;523(3):773-779. (*Correspondence)
  5. Tsai YC, Hohmann J, El-Shazly M, Chang LK, Dankó B, Kúsz N, Hsieh CT, Hunyadi A, Chang FR (2020) Bioactive constituents of Lindernia crustacea and its anti-EBV effect via Rta expression inhibition in the viral lytic cycle. J Ethnopharmacol. 2020 Mar 25;250:112493.
  6. Vágvölgyi M, Girst G, Kúsz N, Ötvös SB, Fülöp F, Hohmann J, Servais JY, Seguin-Devaux C, Chang FR, Chen MS, Chang LK, Hunyadi A (2019) Less cytotoxic Less cytotoxic protoflavones as antiviral agents: protoapigenone 1′-O-isopropyl ether shows improved selectivity against the Epstein-Barr virus lytic cycle. Int J Mol Sci. 20(24). Pii:E6269
  7. Huang JY, Kang ST, Chen IT, Chang LK, Lin SS, Kou GH, Chu CY, Lo CF (2017) Shrimp miR-10a is co-opted by white spot syndrome virus to increase viral gene expression and viral replication. Front Immunol. 8:1084
  8. Huang PH, Huang TY, Cai PS, Chang LK* (2017) Role of Litopenaeus vannamei Yin Yang 1 in the regulation of the white spot syndrome virus immediate-early gene ie1. J Virol. 91(6). pii: e02314-16. (*Correspondence)
  9. Huang HH, Chen CS, Wang WH, Hsu SW, Tsai HH, Liu ST, Chang LK* (2017) TRIM5promotes ubiquitination of Rta from Epstein-Barr virus to attenuate lytic progression. Front Microbiol. 7:2129. (*Correspondence)
  10. Chang TH, Wang SS, Chen LW, Shih YJ, Chang LK, Liu ST, Chang PJ. (2016) Regulation of the aboundance of Kaposi’s sarcoma-associated herpesvirus ORF50 protein by oncoprotein MDM2. PLoS Pathog. 12(10):e1005918.
  11. Hung CC, Kuo CW, Wang WH, Chang TH, Chang PJ, Chang LK*, Liu ST*. (2015) Transcriptional activation of Epstein-Barr virus BRLF1 by USF1 and Rta. J Gen Virol. 96(9):2855-66. (*Correspondence)
  12. Wang WH, Kuo CW, Chang LK, Hung CC, Chang TH, Liu ST. (2015) Assembly of Epstein-Barr virus capsid in promyelocytic leukemia nuclear bodies. J Virol. 89(17):8922-31.
  13. Yang YC, Feng TH, Chen TY, Huang HH, Hung CC, Liu ST, Chang LK* (2015) RanBPM regulates Zta-mediated transcriptional activity in Epstein-Barr virus. J Gen Virol. 96(8):2336-48. (*Correspondence)
  14. Liu WJ, Lo CF, Kou GH, Leu JH, Lai YJ, Chang LK, Chang YS (2015) The promoter of the white spot syndrome virus immediate-early gene WSSV108 is activated by the cellular KLF transcription factor. Dev Comp Immunol. 49(1):7-18.
  15. Huang PH, Lu SC, Yang SH, Cai PS, Lo CF, Chang LK* (2014) Regulation of the immediate-early genes of white spot syndrome virus by Litopenaeus vannamei Kruppel-like factor (LvKLF). Dev Comp Immunol. 46:364-372 (*Correspondence)
  16. Lin TY, Chu YY, Yang YC, Hsu SW, Liu ST, Chang LK* (2014) MCAF1 and Rta-activated BZLF1 transcription in Epstein Barr virus. PLoS One. 9(3):e90698. (*Correspondence)
  17. Yang YC, Yoshikai Y, Hsu SW, Saitoh H*, Chang LK* (2013) Role RNF4 in the ubiquitination of Rta of Epstein-Barr virus. J. Biol. Chem. 288:12866-12879. (*Correspondence)
  18. Yang YC and Chang LK* (2013) Role of TAF4 in transcriptional activation by Rta of Epstein-Barr virus. PLoS One. 8(1):e54075 (*Correspondence)
  19. Chang LK*, Huang PH, Shen WT, Yang SH, Liu WJ, Lo CF* (2012) Role of Penaeus monodon Kruppel-like factor (PmKLF) in infection by white spot syndrome virus. Dev Comp Immunol. 36(1):121-129 (*Correspondence)
  20. Wang WH, Chang LK, Liu ST (2011) Molecular interactions of Epstein-Barr virus capsid proteins. J Virol. 85(4):1615-24.
  21. Chen CC, Yang YC, Wang WH, Chen CS, Chang LK* (2011) Enhancement of Zta-activated lytic transcription of Epstein-Barr virus by Ku80. J Gen Virol. 92:661-8. (*Correspondence)
  22. Yiu CY, Chen SY, Chang LK, Chiu YF, Lin TP (2010) Inhibitory effects of resveratrol on the Epstein-Barr virus lytic cycle. Molecules. 15(10):7115-24.
  23. Chou CH, Lieu AS, Wu CH, Chang LK, Loh JK, Lin RC, Chen WJ, Liao HD, Fu WS, Chang CS, Lin CC, Hsu CM, Chio CC, Howng SL, Hong YR (2010) Differential expression of hedgehog signaling components and Snail/E-cadherin in human brain tumors. Oncol Rep. 24(5):1225-1232.
  24. Lieu AS, Cheng TS, Chou CH, Wu CH, Hsu CY, Huang CY, Chang LK, Loh JK, Chang CS, Hsu CM, Howng SL, Hong YR (2010) Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation. Int J Oncol. 37(2):429-436.
  25. Shin YC, Liu BY, Tsai JY, Wu JT, Chang LK, Chang SC (2010) Biochemical characterization of the small ubiquitin-like modifiers of Chlamydomonas reinhardtii. Planta. 232(3):649-662. 
  26. Chang LK, Chuang JY, Nakao M, Liu ST (2010) MCAF1 and synergistic activation of the transcription of Epstein-Barr virus lytic genes by Rta and Zta. Nucleic Acids Res. 38(14): 4687-4700.
  27. Chang FR, Hsieh YC, Chang YF, Lee KH, Wu YC, Chang LK* (2010) Inhibition of the Epstein-Barr virus lytic cycle by moronic acid. Antiviral Res. 85(3):490-495. (*Correspondence)