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Core faculty

Professor and Chairman Kung-Ta Lee

Kung-Ta Lee

Title Professor and Chairman
Education Ph.D., Department of Biotechnology, The University of Tokyo
Research Expertise Plant cell culture, Applied microbiology, Industrial scale purification of medicinal proteins
LAB BioAnalytical Chemistry aFermentation Lab. (AC-117)
TEL +886-2-3366-4436
Personal webpage  





  1. Huang HT, Lo IW, Liao GY, Lin YC, Shen YC, Huang HC, Li TL, *Lee KT, Kuo YH, Liaw CC (2022) Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley. Front Chem, doi: 10.3389/fchem. 2022.1003356.(SCI)
  2. Lin YC, Wu CY, Huang HT, Lu MK, Hu WS, Lee KT. Bacillus subtilis natto Derivatives Inhibit Enterococcal Biofilm Formation via Restructuring of the Cell Envelope. Front Microbiol 2021; 12: 785351.(SCI)
  3. Lin YC, Chen EH, Chen RP, Dunny GM, Hu WS, Lee KT. Probiotic Bacillus Affects Enterococcus faecalis Antibiotic Resistance Transfer by Interfering with Pheromone Signaling Cascades. Appl Environ Microbiol 2021; 87(13): e0044221.(SCI)
  4. Kao WY, Hsiang CY, Ho SC, Ho TY, Lee KT. Novel serotonin-boosting effect of incense smoke from Kynam agarwood in mice: The involvement of multiple neuroactive pathways. J Ethnopharmacol 2021; 275: 114069.(SCI)
  5. Huang HT, Liaw CC, Lin YC, Liao GY, Chao CH, Chiou CT, Kuo YH, Lee KT. New Diterpenoids from Mesona procumbens with Antiproliferative Activities Modulate Cell Cycle Arrest and Apoptosis in Human Leukemia Cancer Cells. Pharmaceuticals (Basel) 2021; 14(11).(SCI)
  6. Huang HT, Liaw CC, Chiou CT, Lee KT, Kuo YH. Mesonosides A-H, primeverose derivatives from Mesona procumbens suppress adipogenesis by downregulating PPAR gamma and C/EBP alpha in 3T3-L1 cells. Journal of Food and Drug Analysis 2021; 29(3): 448-67.(SCI)
  7. Huang HT, Liaw CC, Chiou CT, Kuo YH, Lee KT. Triterpene Acids from Mesona procumbens Exert Anti-inflammatory Effects on LPS-Stimulated Murine Macrophages by Regulating the MAPK Signaling Pathway. J Agric Food Chem 2021; 69(22): 6271-80.(SCI)
  8. Chen SP, Chen EH, Yang SY, Kuo PS, Jan HM, Yang TC, Hsieh MY, Lee KT, Lin CH, Chen RP. A Systematic Study of the Stability, Safety, and Efficacy of the de novo Designed Antimicrobial Peptide PepD2 and Its Modified Derivatives Against Acinetobacter baumannii. Front Microbiol 2021; 12: 678330.(SCI)
  9. Chen EH, Weng CW, Li YM, Wu MC, Yang CC, Lee KT, Chen RP, Cheng CP. De Novo Design of Antimicrobial Peptides With a Special Charge Pattern and Their Application in Combating Plant Pathogens. Front Plant Sci 2021; 12: 753217.(SCI)
  10. Tsai, DH, Chung, CH, Lee, KT. Antrodia cinnamomea induces autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway in colorectal cancer cells. Sci Rep 2018; 8(1): 17424.(SCI)
  11. Kao, WY, Hsiang, CY, Ho, SC, Ho, TY, Lee, KT. Chemical Profiles of Incense Smoke Ingredients from Agarwood by Headspace Gas Chromatography-Tandem Mass Spectrometry. Molecules 2018; 23(11).(SCI)
  12. Hsieh, SC, Wang, JH, Lai, YC, Su, CY, Lee, KT. Production of 1-Dodecanol, 1-Tetradecanol, and 1,12-Dodecanediol through Whole-Cell Biotransformation in Escherichia coliAppl Environ Microbiol 2018; 84(4).(SCI)
  13. Chung, CH, Yeh, SC, Tseng, HC, Siu, ML, Lee, KT. Chemical quality evaluation of Antrodia cinnamomea fruiting bodies using phytomics similarity index analysis. J Food Drug Anal 2016; 24(1): 173-8.(SCI)
  14. Wang JH, Lin HH, Liu CT, Lin TC, Liu LY, Lee KT. Transcriptomic analysis reveals that ROS and genes encoding LTPs are associated with tobacco hairy root growth and branch development. Mol Plant Microbe Interact 2014: 27(7): 678-87.(SCI)
  15. Kuo HJ, Wei ZY, Lu PC, Huang PL, Lee KT. Bioconversion of pinoresinol into matairesinol using recombinant Escherichia coliAppl Environ Microbiol 2014: 80(9): 2687-92.(SCI)
  16. Chung CH, Yeh SC, Chen CJ, Lee KT. Coenzyme Q0 from Antrodia cinnamomea in Submerged Cultures Induces Reactive Oxygen Species-Mediated Apoptosis in A549 Human Lung Cancer Cells. Evid Based Complement Alternat Med 2014; 2014: 246748.(SCI)
  17. Huang Y, Su CY, Kuo HJ, Chen YH, Huang PL, Lee KT. A comparison of strategies for multiple-gene co-transformation via hairy root induction. Appl Microbiol Biotechnol 2013; 97(19): 8637-47.(SCI)
  18. Kuo LC, Wu RY, Lee KT. A process for high-efficiency isoflavone deglycosylation using Bacillus subtilis natto NTU-18. Appl Microbiol Biotechnol 2012; 94(5): 1181-8.(SCI)
  19. Liu CT, Lee KB, Wang YS, Peng MH, Lee KT, Suzuki S, Suzuki T, Oyaizu H. Involvement of the azorhizobial chromosome partition gene (parA) in the onset of bacteroid differentiation during Sesbania rostrata stem nodule development. Appl Environ Microbiol. 2011; 77(13): 4371-82. (SCI)
  20. Lee CC, Ho H, Lee KT, Jeng ST, Chiang BL. Construction of a Der p2-transgenic plant for the alleviation of airway inflammation. Cell Mol Immunol. 2011; 8(5): 404-14. (SCI)
  21. Hsu RL, Lee KT, Wang JH, Lee LY, Chen RP. Amyloid-degrading ability of nattokinase from Bacillus subtilis Natto. J Agric Food Chem. 2009; 57(2): 503-8. (SCI)
  22. Kuo LC, Lee KT. Cloning, expression, and characterization of two beta-glucosidases from isoflavone glycoside-hydrolyzing Bacillus subtilis Natto. J Agric Food Chem. 2008; 56(1): 119-25. (SCI)
  23. Lee KT, Chen SC, Chiang BL, Yamakawa T. Heat-inducible production of beta-glucuronidase in tobacco hairy root cultures. Appl Microbiol Biotechnol. 2007; 73(5): 1047-53. (SCI)
  24. Chen SC, Liu HW, Lee KT, Yamakawa T. High-efficiency Agrobacterium rhizogenes-mediated transformation of heat inducible sHSP18.2-GUS in Nicotiana tabacum.Plant Cell Rep. 2007; 26(1): 29-37. (SCI)
  25. Kuo LC, Cheng WY, Wu RY, Huang CJ, Lee KT. Hydrolysis of black soybean isoflavone glycosides by Bacillus subtilis Natto. Appl Microbiol Biotechnol. 2006; 73(2): 314-20. (SCI)
  26. Chen CY, Lee KT, Liu TH, Liu WH. Callus induction of Podophyllum pleianthum hance and the detection of podophyllotoxin. Taiwanese J Agric Chem & Food Sci. 2004; 42(6): 412-20.
  27. Lee KT, Hirano H, Yamakawa T, Kodama T, Igarashi Y, Shimomura K. Responses of transformed root culture of Atropa belladonna to salicylic acid stress. J Biosci Bioeng. 2001; 91(6): 586-9. (SCI)
  28. Lee KT, Suzuki T, Yamakawa T, Kodama T, Igarashi Y, Shimomura K. Production of tropane alkaloids by transformed root cultures of Atropa belladonna in stirred bioreactors with a stainless steel net. Plant Cell Rep. 1999; 18(7): 567-71-71. (SCI)
  29. Lee KT, Yamakawa T, Kodama T, Shimomura K. Effects of chemicals on alkaloid production by transformed roots of belladonna. Phytochemistry. 1998; 49(8): 2343-7. (SCI)
  30. Lee KT, Yamakawa T, Kodama T, Igarashi Y, Shimomura K. Effects of aeration on tropane alkaloid production by transformed root of Atropa belladonna in flask cultures. J Ferment Bioeng. 1998; 86(6): 614-6. (SCI)