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李昆達 教授兼系主任
連絡資訊


李昆達教授

李昆達 (Kung-Ta Lee) 教授兼系主任

國立臺灣大學 生命科學院 生化科技學系

  • 電話 :(O) 3366-4436 ;(L) 3366-4437
  • 傳真 :2364-0961
  • 辦公室 :農化館 117 室
  • 研究室 :醱酵學研究室 (農化館 119、121 室)
  • E-mail :ktlee@ntu.edu.tw
  • 研究專長 :植物二次代謝物與植物細胞培養、應用微生物學、醫用酵素工業純化
  • 授課領域 :植物細胞培養與工業應用、應用微生物學 、應用微生物學實驗、醱酵學

學歷


  • 東京大學 應用生命工學專攻 博士(1995/04 ~ 1998/03)
  • 臺灣大學 農業化學研究所 碩士(1989/09 ~ 1991/06)
  • 臺灣大學 農業化學系 學士(1985/09 ~ 1989/06)

研究焦點

主要經歷


  • 生化科技學系暨研究所 系主任(2022/08 ~ now)
  • 生化科技學系暨研究所 教授(2014/08 ~ now)
  • 生化科技學系暨研究所 副教授(2007/08 ~ 2014/07)
  • 生化科技學系 助理教授(2003/08 ~ 2007/07)
  • 微生物與生化學研究所 副教授(2007/08 ~ 2009/07)
  • 微生物與生化學研究所 助理教授(2003/08 ~ 20007/07)
  • 農業化學系 助理教授(2000/08 ~ 2003/07)
  • 生物技術開發中心 研究員(1998/10 ~ 2000/08)
  • 東京大學 博士後研究員(1998/04 ~ 1998/09)
  • 臺灣多胺公司 研究員(1991/07 ~ 1995/01)

榮譽獎項


  • 日本交流協會 獎學金(1995/04 ~ 1998/03)
  • 日本學術振興會 研究獎助金(1998/04 ~ 1998/09)

代表著作


  1. Lin YC, Wu CY, Huang HT, Lu MK, Hu WS, *Lee KT (2021) Bacillus subtilis natto derivatives inhibit enterococcal biofilm formation via restructuring of the cell envelope. Frontiers in Microbiology, 12:785351. doi: 10.3389.

  2. Huang HT, Liaw CC, Lin YC, Liao GY, Chao CH, Chiou CT, Kuo YH, *Lee KT (2021) New Diterpenoids from Mesona procumbens with antiproliferative activities modulate cell cycle arrest and apoptosis in human leukemia cancer cells. Pharmaceuticals, 14, 1108. https://doi.org/10.3390/ph14111108.

  3. Huang HT, Liaw CC, Lin YC, Chiou CT, *Lee KT, *Kuo YH (2021) Mesonosides A-H, primeverose derivatives from Mesona procumbens suppress adipogenesis by downregulating PPARg and C/EBPa in 3T3-L1 cells. Journal of Food and Drug Analysis, 29(3), Article 5.

  4. Lin YC, Chen HL, Chen PY, Dunny GM, Hu WS, *Lee KT (2021) Probiotic Bacillus affects Enterococcus faecalis antibiotic resistance transfer by interfering with pheromone signaling ccascades. Applied and Environmental Microbiology, 87(13) e00442-21.

  5. Huang HT, Liaw CC, Lin YC, Chiou CT, Kuo YH, *Lee KT (2021) Triterpene acids from Mesona procumbens exert anti-inflammatory effects on LPS-stimulated murine macrophages by regulating the MAPK signaling pathway. Journal of Agricultural and Food Chemistry, 69, 6271-6280.

  6. Kao WY, Hsiang CY, Ho SC, Ho TY, *Lee KT (2021) Novel serotonin-boosting effect of incense smoke from Kynam agarwood in mice: The involvement of multiple neuroactive pathways. Journal of Ethnopharmacology, 275 (2021) 114069.

  7. Tsai DH, Chung CH, *Lee KT (2018) Antrodia cinnamomea induces autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway in colorectal cancer cells. Scientific Reports 8, 17424; doi:10.1038/s41598-018-35780-y.

  8. Hsieh SC, Wang JH, Lai YC, Su CY, *Lee KT (2018) Production of 1-dodecanol, 1-tetradecanol, and 1, 12-dodecanediol through whole-cell biotransformation in Escherichia coli. Appl Environ Microb 84: e01806-17.

  9. Kao WY, Hsiang CY, Ho SC, *Ho TY, *Lee KT (2018) Chemical profiles of incense smoke ingredients from agarwood by headspace gas chromatography-tandem mass spectrometry. Molecules 23, 2969; doi:10.3390.

  10. Chung, CH, Yeh, SC, Tseng, HC, Siu, ML, Lee, KT. Chemical quality evaluation of Antrodia cinnamomea fruiting bodies using phytomics similarity index analysis. J Food Drug Anal 2016; 24(1): 173-8.(SCI)
  11. Wang JH, Lin HH, Liu CT, Lin TC, Liu LY, Lee KT. Transcriptomic analysis reveals that ROS and genes encoding LTPs are associated with tobacco hairy root growth and branch development. Mol Plant Microbe Interact 2014: 27(7): 678-87.(SCI)
  12. Kuo HJ, Wei ZY, Lu PC, Huang PL, Lee KT. Bioconversion of pinoresinol into matairesinol using recombinant Escherichia coliAppl Environ Microbiol 2014: 80(9): 2687-92.(SCI)
  13. Chung CH, Yeh SC, Chen CJ, Lee KT. Coenzyme Q0 from Antrodia cinnamomea in Submerged Cultures Induces Reactive Oxygen Species-Mediated Apoptosis in A549 Human Lung Cancer Cells. Evid Based Complement Alternat Med 2014; 2014: 246748.(SCI)
  14. Huang Y, Su CY, Kuo HJ, Chen YH, Huang PL, Lee KT. A comparison of strategies for multiple-gene co-transformation via hairy root induction. Appl Microbiol Biotechnol 2013; 97(19): 8637-47.(SCI)
  15. Kuo LC, Wu RY, Lee KT. A process for high-efficiency isoflavone deglycosylation using Bacillus subtilis natto NTU-18. Appl Microbiol Biotechnol 2012; 94(5): 1181-8.(SCI)
  16. Liu CT, Lee KB, Wang YS, Peng MH, Lee KT, Suzuki S, Suzuki T, Oyaizu H. Involvement of the azorhizobial chromosome partition gene (parA) in the onset of bacteroid differentiation during Sesbania rostrata stem nodule development. Appl Environ Microbiol. 2011; 77(13): 4371-82. (SCI)
  17. Lee CC, Ho H, Lee KT, Jeng ST, Chiang BL. Construction of a Der p2-transgenic plant for the alleviation of airway inflammation. Cell Mol Immunol. 2011; 8(5): 404-14. (SCI)
  18. Hsu RL, Lee KT, Wang JH, Lee LY, Chen RP. Amyloid-degrading ability of nattokinase from Bacillus subtilis Natto. J Agric Food Chem. 2009; 57(2): 503-8. (SCI)
  19. Kuo LC, Lee KT. Cloning, expression, and characterization of two beta-glucosidases from isoflavone glycoside-hydrolyzing Bacillus subtilis Natto. J Agric Food Chem. 2008; 56(1): 119-25. (SCI)
  20. Lee KT, Chen SC, Chiang BL, Yamakawa T. Heat-inducible production of beta-glucuronidase in tobacco hairy root cultures. Appl Microbiol Biotechnol. 2007; 73(5): 1047-53. (SCI)
  21. Chen SC, Liu HW, Lee KT, Yamakawa T. High-efficiency Agrobacterium rhizogenes-mediated transformation of heat inducible sHSP18.2-GUS in Nicotiana tabacum.Plant Cell Rep. 2007; 26(1): 29-37. (SCI)
  22. Kuo LC, Cheng WY, Wu RY, Huang CJ, Lee KT. Hydrolysis of black soybean isoflavone glycosides by Bacillus subtilis Natto. Appl Microbiol Biotechnol. 2006; 73(2): 314-20. (SCI)
  23. Chen CY, Lee KT, Liu TH, Liu WH. Callus induction of Podophyllum pleianthum hance and the detection of podophyllotoxin. Taiwanese J Agric Chem & Food Sci. 2004; 42(6): 412-20.
  24. Lee KT, Hirano H, Yamakawa T, Kodama T, Igarashi Y, Shimomura K. Responses of transformed root culture of Atropa belladonna to salicylic acid stress. J Biosci Bioeng. 2001; 91(6): 586-9. (SCI)
  25. Lee KT, Suzuki T, Yamakawa T, Kodama T, Igarashi Y, Shimomura K. Production of tropane alkaloids by transformed root cultures of Atropa belladonna in stirred bioreactors with a stainless steel net. Plant Cell Rep. 1999; 18(7): 567-71-71. (SCI)
  26. Lee KT, Yamakawa T, Kodama T, Shimomura K. Effects of chemicals on alkaloid production by transformed roots of belladonna. Phytochemistry. 1998; 49(8): 2343-7. (SCI)
  27. Lee KT, Yamakawa T, Kodama T, Igarashi Y, Shimomura K. Effects of aeration on tropane alkaloid production by transformed root of Atropa belladonna in flask cultures. J Ferment Bioeng. 1998; 86(6): 614-6. (SCI)

其他研究成果