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NTUBST2019

教學分組

廖憶純 副教授
連絡資訊


廖憶純 副教授

廖憶純 (Yi-Chun Liao) 副教授

國立臺灣大學 生命科學院 生化科技學系

  • 電話 :(O) 3366-9682 ;(L) 3366-4442
  • 傳真 :3366-2271
  • 辦公室 :農化二館 513 室
  • 研究室 :細胞生物學研究室 (農化二館 513 室)
  • E-mail :yliao@ntu.edu.tw
  • 研究專長 :生物化學、分子生物學、細胞生物學
  • 授課領域 :生物化學實驗、分子生物學、生物化學、專題研究、專題討論

學歷


  • 國立臺灣大學農業化學研究所  博士 (1996/09 ~ 2002/06)
  • 國立臺灣大學農業化學系  學士 (1992/09 ~ 1996/06)

研究焦點


CTEN 促進腫瘤發生的分子機轉和訊息傳導途徑
CTEN (C-terminal tesin like) 是一種屬於 tensin 家族的集中附著點 (focal adhesion) 蛋白質,集中附著點連接細胞外基質與細胞內的細胞骨架,於細胞附著、遷移、增生、分化與基因表現等方面都扮演重要角色,tensin 表現失調會造成細胞轉型與癌症發生。CTEN 主要調節細胞骨架重組、參與細胞附著與遷移的過程,CTEN 也能增強腫瘤細胞增生、遷移及侵入的能力,以促進腫瘤發生,在胸腺腫瘤、肺癌、胃癌、大腸癌及乳癌中皆發現 CTEN 高度表現的現象。根據我們之前的研究顯示,CTEN 的表現受表皮生長因子受器 (epidermal growth factor receptor, EGFR) 的活化而誘導,並有助於乳癌的侵犯性,除了集中附著點,大量的 CTEN 也在大腸癌細胞的細胞核中被發現,這是正常細胞中沒有被觀察到的現象,我們也證明 CTEN 在大腸癌細胞核中可與 beta-catenin 結合並促進腫瘤發生。
 
本研究室探討的主題為:

  • 參與調控 CTEN 受 EGF 誘導表現的訊息傳導路徑及調節因子;
  • 運送 CTEN 至細胞核的機制;
  • 細胞核 CTEN 與促進腫瘤發生的關連性。

藉由瞭解位於細胞核的 CTEN 在腫瘤發生過程中所扮演的角色,進而闡明 CTEN 促進腫瘤發生的分子機轉,預期可進而提供發展癌症治療的新標的。

主要經歷


  • 生化科技學系 副教授 (2016/08 ~ now)
  • 生化科技學系 助理教授 (2010/08 ~ 2016/07)
  • 美國加州大學 Davis 分校醫學院生化與分子醫學系 專案計畫助研究員 (2008/09 ~ 2010/07)
  • 美國加州大學 Davis 分校 博士後研究員 (2003/09 ~ 2008/08)
  • 國立臺灣大學農業化學系 博士後研究員 (2002/08 ~ 2003/07)

榮譽獎項


  • 臺灣大學傑出教學獎 (2018)
  • 臺灣大學優良教學獎 (2017)
  • 臺灣大學優良教學獎 (2016)
  • 臺灣大學優良教學獎 (2015)
  • 臺灣大學優良教學獎 (2014)
  • 臺灣大學優良教學獎 (2013)

代表著作


  1. Liao YC*, Lo SH*. Tensins: emerging insights into their domain functions, biological roles and disease relevance. J. Cell Sci. 2021; 134: jcs254029 (*corresponding author) (SCI)
  2. Chang CC, Liu YC, Lin CH, Liao YC*. Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells. Biochem. Biophys. Res. Commun. 2021; 534:53-58 (*corresponding author) (SCI)
  3. Wu WM, Liao YC*. Downregulation of C-terminal tensin-like protein (CTEN) suppresses prostate cell proliferation and contributes to acinar morphogenesis. Int. J. Mol. Sci. 2018; 19: 3190 (*corresponding author) (SCI)
  4. Hsieh SC, Hsieh WJ, Chiang AN, Su NW, Yeh YT, Liao YC*. The methanol-ethyl acetate partitioned fraction from Chinese olive fruits inhibits cancer cell proliferation and tumor growth by promoting apoptosis through the suppression of NF-κB signaling pathway. Food Funct. 2016; 7:4797-4803 (*corresponding author) (SCI)
  5. Hsieh CC#, Liao CC#, Liao YC#, Hwang LS, Wu LY, Hsieh SC. Proteomic changes associated with metabolic syndrome in a fructose-fed rat model. J. Food Drug Anal. 2016; 24: 754-761. (#equal contribution) (SCI)
  6. Yang K, Wu WM, Chen YC, Lo SH, Liao YC*. ΔNp63α transcriptionally regulates the expression of CTEN that is associated with prostate cell adhesion. PLoS One 2016; 11: e0147542. (*corresponding author) (SCI)
  7. Chen NT, Kuwabara Y, Conley C, Liao YC, Hong SY, Chen M, Shih YP, Chen HW, Hsieh F, Lo SH. Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. Gene 2013; 520: 90-97. (SCI)
  8. Chang JC#, Liao YC#, Yang CC, Wang AY. The purine-rich DNA binding protein OsPuralpha participates in the regulation of the rice sucrose synthase 1 gene expression. Physiol. Plant. 2011; 143: 219-234. (#equal contribution) (SCI)
  9. Albasri A, Al-Ghamdi S, Fadhil W, Aleskandarany M, Liao YC, Jackson D, Lobo DN, Lo SH, Kumari R, Durrant L, Watson S, Kindle KB, Ilyas M. Cten signals through integrin-linked kinase (ILK) and may promote metastasis in colorectal cancer. Oncogene 2011; 30: 2997-3002. (SCI)
  10. Shih YP, Liao YC, Lin Y, Lo SH. DLC1 negatively regulates angiogenesis in a paracrine fashion. Cancer Res. 2010; 70: 8270-8275. (SCI)
  11. Lin Y, Chen NT, Shih YP, Liao YC, Xue L, Lo SH. DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Oncogene 2010; 29: 3010-3016. (SCI)
  12. Liao YC, Chen NT, Shih YP, Dong Y, Lo SH. Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer through beta-catenin. Cancer Res. 2009; 69: 4563-4566. (SCI)
  13. Kuo CJ, Huang LC, Liao YC, Chang CT, Sung HY. Biochemical characterization of a novel chitotriosidase from suspension-cultured bamboo (Bambusa oldhamii) cells. Bot. Stud. 2009; 50: 281-289. (SCI)
  14. Liao YC, Shih YP, Lo SH. Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function. Cancer Res. 2008; 68: 7718-7722. (SCI)
  15. Liao YC, Lo SH. Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liver. Int. J. Biochem. Cell Biol. 2008; 40: 843-847. (SCI)
  16. Kuo CJ, Liao YC, Yang JH, Huang LC, Chang CT, Sung HY. Cloning and characterization of an antifungal class III chitinase from suspension-cultured bamboo (Bambusa oldhamii) cells. J. Agric. Food Chem. 2008; 56: 11507-11514. (SCI)
  17. Katz M, Amit I, Citri A, Shay T, Carvalho S, Lavi S, Milanezi F, Lyass L, Amariglio N, Jacob-Hirsch J, Ben-Chetrit N, Tarcic G, Lindzen M, Avraham R, Liao YC, Trusk P, Lyass A, Rechavi G, Spector NL, Lo SH, Schmitt F, Bacus SS, Yarden Y. A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. Nat. Cell Biol. 2007; 9: 961-969. (SCI)
  18. Liao YC, Si L, devere White RW, Lo SH. The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. J. Cell Biol. 2007; 176: 43-49. (SCI)
  19. Chiang MK, Liao YC, Kuwabara Y, Lo SH. Inactivation of tensin3 in mice results in growth retardation and postnatal lethality. Dev. Biol. 2005; 279: 368-377. (SCI)
  20. Cui Y, Liao YC, Lo SH. Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3. Mol. Cancer Res. 2004; 2: 225-232. (SCI)
  21. Liao YC, Wang AY. Sugar-modulated gene expression of sucrose synthase in suspension- cultured cells of rice. Physiol. Plant. 2003; 118: 319-327. (SCI)
  22. Sayion Y, Huang YW, Chen HM, Liao YC, Wang AY. Expression and Characterization of rice sucrose synthase in Escherichia coliFood. Sci. Agri. Chem. 1999; 1: 122-128.

其他研究成果