My laboratory applies prospective cohort and intervention approaches to study etiology of cardiometabolic diseases with focus on genetic and environmental factors. In recent 10 years, we used omics techniques (genomics, transcriptomics and metabolomics) to dissect etiology of hypertension, obesity, and metabolic and inflammatory diseases and established risk assessment and drug response models. We deploy dimension reduction technique to find influential dietary patterns which is then associated with disease and subclinical disorders. In order to contribute to disease prevention, we design and evaluate efficacy of therapeutic diets with multiple beneficial components to lower blood pressure and to control asthma. At the same time, metabolomics and transcriptomics approach are used to characterize plant foods which will then be categorized and used to tailor individualized therapeutic diets.