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ntubst2019EN

Faculty

Associate Professor Edward Chern
  • 發布單位:Department of Biochemical Science and Technology
Info


Associate Professor Edward Chern

Edward Chern

Title Associate Professor 
Education Ph.D., Dept. Biophysics & Biochemistry, School of Science, The University of Tokyo
Research Expertise Cancer stem cell,Cell therapy and Regenerative medicine
LAB Stem Cell and Regenerative Medicine Lab. (AC2-309)
TEL +886-2-3366-4440
E-mail edchern@ntu.edu.tw
Personal webpage https://niche2010ntubst.wixsite.com/mysite

Research


A. Human induced pluripotent stem cell biology and application

  • Mechanism of cell reprogramming
  • iPSC generation
  • Differentiation of hepatic/pancreatic cells from human iPS cell
  • Differentiation of endothelial cells from human iPS cell

B. Cancer stem cell (liver cancer and colon cancer)

  • Self-renewal mechanism of cancer stem cells.
  • Screening novel cancer stem cell surface markers by phage display system.

C. Drug delivery (nanoparticle)

  • HCC and Colon cancer target-drug developing.

Publications


 

  1. Chang PH, Chao HM, Chern E*, Hsu SH*. Chitosan 3D cell culture system promotes naïve-like features of human induced pluripotent stem cells: A novel tool to sustain pluripotency and facilitate differentiation Biomaterials, 2021 Jan;268:120575. (SCI, *corresponding author)​​
  2. Wang TW#, Chern E#, Hsu CW, Tseng KC, Chao HM. SIRT1-mediated expression of CD24 and epigenetic suppression of novel tumor suppressor miR-1185-1 increases colorectal cancer stemness. Cancer Research, 2020, online published doi: 10.1158/0008-5472.CAN-19-3188  (SCI, #co-first author)
  3. Chen YH, Lin DC, Chern E, Huang YY. The use of micro-needle arrays to deliver cells for cellular therapies. Biomed Microdevices, 2020 Sep 5;22(4):63. (SCI)​​
  4. Chao YC, Hong YJ, Lee CY, Zhuang SC, Wu MT, Lee YY, Lee HY, He YS, Yu HY, Huang YZ, Chern E*, Jiang HR*. NanoMuscle: Controllable Contraction and Extension of Mechanically Interlocked DNA Origami. Nanoscale, 2020,12, 2992-2998 (SCI, *corresponding author)​​
  5. Chao HM, Chern E*Patient-derived induced pluripotent stem cells for models of cancer and cancer stem cell research. Journal of the Formosan Medical Association 2018, 117(12):1046-1057 (SCI, *corresponding author)
  6. Chou MJ, Yu HY, Hsia RJ, Chen YH, Hung TT, Chao HM, Chern E*, Huang YY*. Highly efficient Intracellular protein delivery by cationic polyethyleneimine-modified gelatin nanoparticle. Materials 2018, 11(2), 301 (SCI, *corresponding author)
  7. Chang PH, Sekine K, Chao HM, Hsu Sh*, Chern E *. Chitosan promotes cancer progression and stem cell properties in association with Wnt signaling in colon and hepatocellular carcinoma cells. Scientific Reports. 2017; Apr 3;8:45751. (SCI, *corresponding author)
  8. Chao HM, Huang HX, Chang PH, Tseng KC, Miyajima A, Chern E*. Y-box binding protein-1 promotes hepatocellular carcinoma-initiating cell progression and tumorigenesis via Wnt/β-catenin pathway. Oncotarget. 2017;10;8(2):2604-2616 (SCI, *corresponding author)
  9. Kido T, Koui Y, Suzuki K, Kobayashi A, Miura Y, Chern EY, Tanaka M, Miyajima A. CPM is a useful cell surface marker to isolate expandable bi-potential liver progenitor cells derived from human iPS cells. Stem Cell Reports. 2015; 5: 1-8 (SCI)
  10. Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen YR (Chern EY), Sekine K, Kido T, Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T, Miyajima A. Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Proc Natl Acad Sci U S A. 2012; 109(11): 4263-8. (SCI)
  11. Chen YR (Chern EY), Sekine K, Nakamura K, Yanai H, Tanaka M, Miyajima A. Y-box binding protein-1 down-regulates expression of carbamoyl phosphate synthetase-I by suppressing CCAAT enhancer-binding protein-alpha function in mice. Gastroenterology. 2009; 137(1): 330-40. (SCI)
  12. Sekine K, Chen YR (Chern EY), Kojima N, Ogata K, Fukamizu A, Miyajima A. Foxo1 links insulin signaling to C/EBPα and regulates gluconeogenesis during liver development. The EMBO journal. 2007; 26(15): 3607-15. (SCI)
  13. Huang CL, Chen YR (Chern EY), Liu WH. Production of androstenones from phytosterol by mutants of Mycobacterium spEnzyme and microbial technology. 2006; 39(2): 296-300. (SCI)
  14. Chen YR (Chern EY), Huang HH, Cheng YF, Tang TY, Liu WH. Expression of a cholesterol oxidase gene from Arthrobacter simplex in Escherichia coli and Pichia pastorisEnzyme and microbial technology. 2006; 39(4): 854-60. (SCI)

Courses Taught


  • Cell Biology (0,3); 1/1
  • Frontiers of Stem Cell and Regenerative Medicine (2,0); 1/1
  • Applied Microbiology and Biotechnology (2,0); 1/5
  • Applied Microbiology and Biotechnology laboratory (1,0); 1/3