Skip to main content



Professor Bi-Fong Lin
  • 發布單位:Department of Biochemical Science and Technology

Bi-Fong Lin Professor

Bi-Fong Lin

Title Professor
Education Ph.D., Dept of Nutritional Sciences, University of California at Berkeley
Research Expertise Nutritional chemistry, Nutritional immunology, Cell culture
LAB Nutritional Biochemical Technology Lab.(AC2-409)
TEL +886-2-3366-4451
Personal webpage  


  • Health promoting effects of dietary factors on Immunomodulation: (1) Effects of diets on autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, etc. in murine models; (2) Effects of diets on allergic diseases such as asthma and allergic rhinitis, etc. in murine models; (3) Effects of diets on immunodysregulation-related chronic diseases, such as metabolic syndrome, in murine models.
  • Folate-related studies: (1) Folate status in Taiwan; (2) Folate contents in food; (3) Effects of folate on immune modulations.
  • Screening systems for dietary factors exerting health promoting effects, especially by (1) anti-inflammatory; (2) immunomodulation


  1. Wang LC, Chiang BL, Huang YM, Shen PT, Huang HY, Lin BF. Lower vitamin D levels in the breast milk is associated with atopic dermatitis in early infancy. Pediatr Allergy Immunol 2020; 31(3): 258-64.(SCI)
  2. Huang HY, Hsu T, Lin BF. Gamma-aminobutyric acid decreases macrophages infiltration and suppresses inflammatory responses in renal injury. J Funct Food 2019; 60: 10.(SCI)
  3. Hung LH, Wu CH, Lin BF, Hwang LS. Hyperimmune colostrum alleviates rheumatoid arthritis in a collagen-induced arthritis murine model. J Dairy Sci 2018; 101(5): 3778-87.(SCI)
  4. Pan WH, Yeh NH, Yang RY, Lin WH, Wu WC, Yeh WT, Sung MK, Lee HS, Chang SJ, Huang CJ, Lin BF, Chiang MT. Vegetable, fruit, and phytonutrient consumption patterns in Taiwan. J Food Drug Anal 2018; 26(1): 145-53.(SCI)
  5. Wu CH, Huang TC, Lin BF. Folate deficiency affects dendritic cell function and subsequent T helper cell differentiation. J Nutr Biochem 2017; 41: 65-72.(SCI)
  6. Lu HY, Lin BF. Wild bitter melon alleviates dextran sulphate sodium-induced murine colitis by suppressing inflammatory responses and enhancing intestinal regulatory T cells. J Funct Foods 2016; 23: 590-600.(SCI)
  7. Chen ML, Hsieh CC, Chiang BL, Lin BF. Triterpenoids and Polysaccharide Fractions of Ganoderma tsugae Exert Different Effects on Antiallergic Activities. Evid Based Complement Alternat Med 2015; 2015: 754836.(SCI)
  8. Lin BF, Chiang BL, Ma Y, Lin JY, Chen ML. Traditional Herbal Medicine and Allergic Asthma. Evid Based Complement Alternat Med 2015; 2015: 510989.(SCI)
  9. Chen ML, Wu CH, Hung LS, Lin BF. Ethanol Extract of Perilla frutescens Suppresses Allergen-Specific Th2 Responses and Alleviates Airway Inflammation and Hyperreactivity in Ovalbumin-Sensitized Murine Model of Asthma. Evid Based Complement Alternat Med 2015; 2015: 324265.(SCI)
  10. Wang CH, Hsieh SC, Wang HJ, Chen ML, Lin BF, Chiang BH, Lu TJ. Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium. J Agric Food Chem 2014; 62(3): 634-41.(SCI)
  11. Pan WH, Chang YP, Yeh WT, Guei YS, Lin BF, Wei IL, Yang FL, Liaw YP, Chen KJ, Chen WJ. Co-occurrence of Anemia, Marginal Vitamin B6, and Folate Status and Depressive Symptoms in Older Adults. J Geriatr Psychiatry Neurol. 2012; 25(3): 170-8. (SCI)
  12. Chao WW, Lin BF. Hepatoprotective Diterpenoids Isolated from Andrographis paniculataChin Med. 2012; 3(3): 136-43.
  13. Hsieh CC, Lin BF. Dietary factors regulate cytokines in murine models of systemic lupus erythematosus. Autoimmun Rev. 2011. (SCI)
  14. Hong YH, Wang SC, Hsu C, Lin BF, Kuo YH, Huang CJ. Phytoestrogenic compounds in alfalfa sprout (Medicago sativa) beyond coumestrol. J Agric Food Chem. 2011; 59(1): 131-7. (SCI)
  15. Chen KJ, Pan WH, Lin YC, Lin BF. Trends in folate status in the Taiwanese population aged 19 years and older from the Nutrition and Health Survey in Taiwan 1993-1996 to 2005-2008. Asia Pac J Clin Nutr. 2011; 20(2): 275-82. (SCI)
  16. Chen KJ, Pan WH, Huang CJ, Lin BF. Association between folate status, diabetes, antihypertensive medication and age-related cataracts in elderly Taiwanese. J Nutr Health Aging. 2011; 15(4): 304-10. (SCI)
  17. Chao WW, Lin BF. Bioactivities of major constituents isolated from Angelica sinensis (Danggui). Chin Med. 2011; 6(1): 29.
  18. Chao WW, Kuo YH*, Hsieh SL, Lin BF*. Inhibitory effects of ethyl acetate extract of Andrographis paniculata on NF-kappaB trans-activation activity and LPS-induced acute inflammation in mice. Evi Based Complement Alternat Med. 2011; (doi:10.1093/ecam/nep120)(SCI)
  19. Chao WW, Lin BF. Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chin Med. 2010; 5: 17.
  20. Chao WW, Kuo YH, Lin BF. Anti-inflammatory activity of new compounds from Andrographis paniculata by NF-kappaB transactivation inhibition. J Agric Food Chem. 2010; 58(4): 2505-12. (SCI)
  21. Chao WW, Hong YH, Chen ML, Lin BF. Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation. J Ethnopharmacol. 2010; 129(2): 244-9. (SCI)
  22. Lu HY, Hong YH, Lin BF. The feasibility study on the increase of dietary folate intake by the promotion of fruits consumption. Nutr Sci J. 2009; 34(2): 58-67.
  23. Hong YH, Huang CJ, Wang SC, Lin BF. The ethyl acetate extract of alfalfa sprout ameliorates disease severity of autoimmune-prone MRL-lpr/lpr mice. Lupus. 2009; 18(3): 206-15. (SCI)
  24. Hong YH, Chao WW, Chen ML, Lin BF. Ethyl acetate extracts of alfalfa (Medicago sativa L.) sprouts inhibit lipopolysaccharide-induced inflammation in vitro and in vivo. J Biomed Sci. 2009; 16: 64. (SCI)
  25. Chao WW, Kuo YH, Li WC, Lin BF. The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, Angelica sinensis and Morus alba ethyl acetate fractions. J Ethnopharmacol. 2009; 122(1): 68-75. (SCI)
  26. Weng LC, Yeh WT, Bai CH, Chen HJ, Chuang SY, Chang HY, Lin BF, Chen KJ, Pan WH. Is ischemic stroke risk related to folate status or other nutrients correlated with folate intake? Stroke. 2008; 39(12): 3152-8. (SCI)
  27. Lin JY, Li CY, Lin BF. Amaranthus spinosus L. inhibits spontaneous and dexamethasone-induced apoptosis in murine primary splenocytes. J Food Drug Anal. 2008; 16(4): 52-61. (SCIE)
  28. Hong YH, Wang TC, Huang CJ, Cheng WY, Lin BF. Soy isoflavones supplementation alleviates disease severity in autoimmune-prone MRL-lpr/lpr mice. Lupus. 2008; 17(9): 814-21. (SCI)
  29. Chien SC, Chen ML, Kuo HT, Tsai YC, Lin BF, Kuo YH. Anti-inflammatory activities of new succinic and maleic derivatives from the fruiting body of Antrodia camphorata. J Agric Food Chem. 2008; 56(16): 7017-22. (SCI)
  30. Evaluation of the regulatory effects of dietary materials on allergic immune responses by in vitro and in vivo assay. J Chin Agri Chem Soc. 2007; 45(6): 316-26.
  31. Chao WW, Kuo YH, Lin BF. Construction of promoters based immunity screening system and its application on the study of traditional Chinese medicine herbs. J Chin Agri Chem Soc. 2007; 45(4/5): 193-205.
  32. Wu CH, Lin JJ, Lin JY, Lin BF. Effects of different dietary oils and contents on immune responses of ovalbumin sensitized BALB/c mice. Nutr Sci J. 2007; 32(3): 83-93.
  33. Chen ML, Lin BF. Effects of triterpenoid-rich extracts of Ganoderma tsugae on airway hyperreactivity and Th2 responses in vivoInt Arch Allergy Immunol. 2007; 143(1): 21-30. (SCI)
  34. Chen KJ, Shaw NS, Pan WH, Lin BF. Evaluation of folate status by serum and erythrocyte folate levels and dietary folate intake in Taiwanese schoolchildren. Asia Pac J Clin Nutr. 2007; 16 Suppl 2: 572-8. (SCI)
  35. Chen ML, Lin JY, Lin BF. The immunomodulatory effects of Ganoderma tsugae supplementation on immune responses of BALB/c mice. J Chin Agri Chem Soc. 2006; 44(4): 243-9. (in Chinee)
  36. Chen KJ, Shaw NS, Pan WH, Yang FL, Lin BF. Effect of vegetarian diets on vitamin B Status and homocysteine levels in elderly Taiwanes. Nutr Sci J. 2006; 31(4): 117-26.  (in Chinee)
  37. Chen KJ, Shaw NS, Lin BF. The folate status of prenatal follow-up pregnant women at hospital in Taipei. Nutr Sci J. 2006; 31(1): 8-16. (in Chinee)
  38. Lin JY, Chen ML, Lin BF. Ganoderma tsugae in vivo modulates Th1/Th2 and macrophage responses in an allergic murine model. Food Chem Toxicol. 2006; 44(12): 2025-32. (SCI)
  39. Lin JY, Chen ML, Chiang BL, Lin BF. Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model. Int Immunopharmacol. 2006; 6(2): 241-51. (SCI)
  40. Hsieh CC, Huang CJ, Lin BF. Low and high levels of alpha-tocopherol exert opposite effects on IL-2 possibly through the modulation of PPAR-gamma, IkappaBalpha, and apoptotic pathway in activated splenocytes. Nutrition. 2006; 22(4): 433-40. (SCI)
  41. Lin BF, Chiang BL, Lin JY. Amaranthus spinosus water extract directly stimulates proliferation of B lymphocytes in vitro. Int Immunopharmacol. 2005; 5(4): 711-22. (SCI)
  42. Hsieh CC, Lin BF. The effects of vitamin E supplementation on autoimmune-prone New Zealand black x New Zealand white F1 mice fed an oxidised oil diet. Br J Nutr. 2005; 93(5): 655-62. (SCI)
  43. Hsieh CC, Lin BF. Opposite effects of low and high dose supplementation of vitamin E on survival of MRL/lpr mice. Nutrition. 2005; 21(9): 940-8. (SCI)
  44. Chen KJ, Pan WH, Yang FL, Wei IL, Shaw NS, Lin BF. Association of B vitamins status and homocysteine levels in elderly Taiwanese. Asia Pac J Clin Nutr. 2005; 14(3): 250-5. (SCI)
  45. Chen KJ, Pan WH, Shaw NS, Huang RF, Lin BF. Association between dietary folate-rich food intake and folate status of elderly Taiwanese. Asia Pac J Clin Nutr. 2005; 14(3): 244-9. (SCI)
  46. Chen ML, Hsieh CC, Chen KJ, Lin BF.  Association between abdomenal skin fold and daily fluid intake in young adults. Nutr Sci J. 2004; 29(4): 237-43. (in Chinee)
  47. Hong YH and Lin BF. Evaluation of the anti-inflammation screening model of macrophages cell line by the proinflammatory mediators secretions. Nutr Sci J. 2004; 29(3): 159-67. (in Chinee)
  48. Hong YH and Lin BF. Evaluation of the anti-inflammation screening model of macrophages cell line by the proinflammatory mediators secretions. J Chin Agri Chem Soc. 2004; 42(6): 456-65. (in Chinee)
  49. Lin JY, Liu YL, Lin BF, Hsiao CC and Tsai SJ. Antioxidant, antimutagenic and immunomoduatory potentials of Gynura bicolar and Amaranthus gangetcaueJ Chin Agri Chem Soc. 2004; 42(4): 231-41. (in Chinee)
  50. Chen CH, Lin JY, Liu PS, Yang YS, Ding HC, Liao CC, Lin BF. The effect of bifidobacterium longum feeding on intestinal microflora and immune modulation in balb/c mice. J Chin Agri Chem Soc. 2003; 41(5): 336-42. (in Chinee)
  51. Chen IC, Lin BF. Effects of juice extraction on dietary fiber availability of fruits and vegetables. Nutr Sci J. 2003; 28(1): 18-25. (in Chinee)
  52. Hsu HY, Lin BF, Lin JY, Kuo CC, Chiang W. Suppression of allergic reactions by dehulled adlay in association with the balance of TH1/TH2 cell responses. J Agric Food Chem. 2003; 51(13): 3763-9. (SCI)
  53. Hung CJ, Huang PC, Lu SC, Li YH, Huang HB, Lin BF, Chang SJ, Chou HF. Plasma homocysteine levels in Taiwanese vegetarians are higher than those of omnivores. J Nutr. 2002; 132(2): 152-8. (SCI)
  54. Ghandour H, Lin BF, Choi SW, Mason JB, Selhub J. Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins. J Nutr. 2002; 132(6): 1357-60. (SCI)
  55. Wu WM, Chiang BL, Chang SC, Lin BF. Dietary fish oil increases CD8+ T-cells and decreases autoreactive T-cell activity in autoimmune NZB/W F1 mice. J Microbiol Immunol Infect. 2001; 34(1): 41-9. (SCI)
  56. Leh J and Lin BF. Determination of folate contents of commonly consumed vegetables in Taiwan. Nutr Sci J. 2000; 29-37. (in Chinee)
  57. Wu WM, Suen JL, Lin BF, Chiang BL. Tamoxifen alleviates disease severity and decreases double negative T cells in autoimmune MRL-lpr/lpr mice. Immunology. 2000; 100(1): 110-8. (SCI)
  58. Wu WM, Lin BF, Su YC, Suen JL, Chiang BL. Tamoxifen decreases renal inflammation and alleviates disease severity in autoimmune NZB/W F1 mice. Scand J Immunol. 2000; 52(4): 393-400. (SCI)
  59. Wu WM, Chiang BL, Chang SC, Lin BF. Late feeding of dietary fish oil alleviates disease severity and affects macrophage function in autoimmune NZB/W F1 mice. J Microbiol Immunol Infect. 2000; 33(2): 79-86. (SCI)
  60. Lin JY, Lin BF. Effects of weekly vs bi-weekly ovalbumin sensitization protocols in ICR mice. Food Sci Agric Chem. 2000; 2(1): 28-34.
  61. Lin BF, Lai CC, Lin KW, Chiang BL. Dietary oxidized oil influences the levels of type 2 T-helper cell-related antibody and inflammatory mediators in mice. Br J Nutr. 2000; 84(6): 911-7. (SCI)
  62. Lin BF* and Lin RF. Effect of Chinese oil-frying cooking on folate contents in vegetables. J Chin Agri Chem Soc. 1999; 37: 443-454. (in Chinee)
  63. Lin BF, Lin RF, Yeh WT, Pan WH. The Folate Status in Taiwanese Population from the NAHSIT 1993-1996. Nutr Sci J. 1999; 24(1): 99-117.
  64. Chang SC, Chiang BL, Wu WM, Lin BF. Different dietary fats influence serum and tissue lipids and anti-cardiolipin antibody levels in autoimmune-prone NZB/W F1 mice. Br J Nutr. 1999; 81(4): 331-40. (SCI)

Courses Taught

  • Food and Nutrition
  • Introduction to Nutrition and Food
  • Nutritional Chemistry
  • Lab of Nutritional Chemistry
  • Applied Immunology