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Distinguished Professor Ja-An Annie Ho
  • 發布單位:Department of Biochemical Science and Technology

Ja-An Annie Ho Professor

Ja-An Annie Ho

Title Distinguished Professor
Education Ph.D., Cornell University
Research Expertise Biosensor development, Targeted drug delivery system development, Bioanalytical chemistry
LAB BioAnalytical Chemistry and Nanobiomedicine Lab. (AC2-307)
TEL +886-2-3366-4438
Personal webpage


Highlight I Liposomes in Flow Injection Systems

1. Application of Liposomal Bioluminescent Label in the Development of Flow Injection ImmunoAnalytical System [Anal. Chem200577 (11), 3431–3436]; illustrated in Figure 2
2. Application of Ganglioside‐Sensitized Liposomes in a Flow Injection Immunoanalytical System for the Determination of Cholera Toxin [Anal. Chem200779 (1), 246–250].



圖二 (A) Schematic representation of a Flow‐Injection Liposome Immunoanalytical (FILIA) system with bioluminescence detection. (B) Reproducibility of the bioluminescence signal.


Highlight II Development of Electrochemial Immunosensors

1. Electrochemical Immunosensor for Cholera Toxin Using Liposomes and poly(3,4‐ ethylenedioxythiophene)‐Coated Carbon Nanotubes [Anal. Chem200678 (4), 1115–1121]; illustrated in Figure 3.
2. Dual Electrochemical Determination of Glucose and Insulin Using Enzyme and Ferrocene Microcapsules [Biosens. Bioelectron200722, 1147–1153]; illustrated in Figure 4.





圖三 (A) Schematic representation of an electrochemical immunosensor for cholera toxin. (B) Calibration plot for cholera toxin. Inset: Linear portion of the main curve.


圖四 Schematic representation of the encapsulation, biolabeling, and detection of glucose and insulin.


Highlight III Liposomes in Immunoaffinity Chromatographic Biosensors

1. Using Liposomal Fluorescent Biolabels To Develop an Immunoaffinity Chromatographic Biosensing System for Biotin [Anal. Chem200880 (16), 6405–6409]; illustrated in Figure 5.

圖五 Schematic representation of the operation of an immunosensor for the detection of biotin.


  1. Huang, S.-P., Ho, T.-M., Yang, C.-W., Chang, Y.-J., Chen, J.-F., Shaw, N.-S., Horng, J.-C., Hsu, S.-L., Liao, M.-Y., Wu, L.-C., Ho, J.-a. A.* (2017) Chemopreventive Potential of Ethanolic Extracts of Luobuma Leaves (Apocynum venetum L.) in Androgen Insensitive Prostate Cancer. Nutrients, 9, 948. (SCI) DOI:10.3390/nu9090948
  2. Jou, A. F.-J. and Chen, Y.-J., Li, Y., Chang, Y.-F., Lee, J.-J., Liao, A. T., Ho, J.-a. A.* (2017) Target-Triggered, Dual Amplification Strategy for Sensitive Electrochemical Detection of a Lymphoma-associated MicroRNA. Electrochimica Acta, 236, 190-197. (SCI) DOI:10.1016/j.bios.2015.10.012
  3. Li, M.-C. and Chang, Y.-F., Wang, H.-Y., Lin, Y.-X., Kuo, C.-C., Ho, Ja-an Annie*, Lee, C.-C., Su, L.-C. (2017) An innovative application of time-domain spectroscopy on localized surface plasmon resonance sensing. Scientific Reports, 7, 44555. (SCI) DOI: 10.1038/srep44555
  4. Li, Y., Hsieh, C.-H., Lai, C.-W., Chang, Y.-F., Chen, H.-Y., Tsai, C.-F., Ho, J. A., Wu, L.-C. (2017) Tyramine detection using PEDOT:PSS/AuNPs/1-methyl-4-mercaptopyridine modified screen-printed carbon electrode with molecularly imprinted polymer solid phase extraction. Biosensors and Bioelectronics, 87, 142-149. (SCI) DOI:10.1016/j.bios.2016.08.006
  1. Chang, Y.-F.; Fu, C.; Chen, Y.-T.; Chen, C.-C., Chou, C. and Ho, J.-a. A.* (2016) Use of liposomal amplifiers in total internal reflection fluorescence fiber-optic biosensors for protein detection. Biosensors and Bioelectronics, 77, 1201-1207. (SCI) DOI:10.1016/j.bios.2015.10.012
  1. Chang, H.-C. and Ho, J.-a. A.* (2015) Gold Nanocluster-Assisted Fluorescent Detection for Hydrogen Peroxide and Cholesterol Based on the Inner Filter Effect of Gold Nanoparticles. Analytical Chemistry, 87(20), 10362-10367. (SCI) DOI: 10.1021/acs.analchem.5b02452
  2. Lee, M.-t. G, Wang, H.-M., Ho, J.-a. A., Fan, N.-C., Yang, Y.-L.,  Lee, C.-C.*, Chen, S.-C. (2015) Resuscitation Using Liposomal Vasopressin in an Animal Model of Uncontrolled Hemorrhagic Shock. Plos One, 10(7), e0130655. (SCI) DOI: 10.1371/journal.pone.0130655
  3. Chang, Y.-J., Hsu, S.-L., Liu, Y.-T., Lin, Y.-H., Lin, M.-H., Huang, S.-J., Ho, J.-a. A.; Wu, L.-C.* (2015) Gallic Acid Induces Necroptosis via TNF-alpha Signaling Pathway in Activated Hepatic Stellate Cells. Plos One, 10(3), e0120713. (SCI) DOI: 10.1371/journal.pone.0120713
  4. Lu, H.-Y., Chang, Y.-J., Fan, N.-C., Wang, L.-S., Lai, N.-C., Yang, C.-M., Wu, L.-C., Ho, J.-a. A.* (2015) Synergism through combination of chemotherapy and oxidative stress-induced autophagy in A549 lung cancer cells using redox-responsive nanohybrids: A new strategy for cancer therapy. Biomaterials, 42, 30-41. (SCI) DOI: 10.1016/j.biomaterials.2014.11.029
  5. Jou, A. F.-j., Lu, C.-H., Ou, Y.-C., Wang, S.-S., Hsu, S.-L., Willner I* and Ho, J.-a. A.* (2015) Diagnosing the miR-141 prostate cancer biomarker using nucleic acid-functionalized CdSe/ZnS QDs and telomerase. Chemical Science, 6, 659-665. (SCI) DOI: 10.1039/C4SC02104E
  1. Chang, H.-C., Chang, Y.-F., Fan, N.-C. and Ho, J.-a. A. (2014) Facile Preparation of High-Quantum-Yield Gold Nanoclusters: Application to Probing Mercuric Ions and Biothiols. ACS Applied Materials & Interfaces, 6, 18824-18831. (SCI) DOI: 10.1021/am504546f
  2. Tanwar, S., Lu, H.-Y., Magi, E.*, Ho, J.-a. A.* (2014) A 2,4-dinitrophenylhydrazine/kojic acid derivative as a simple colorimetric probe for determination of cupric ions in water. Sensors and Actuators B: Chemical, 203, 204-208. (SCI) DOI: 10.1016/j.snb.2014.06.041 
  3. Lai, Y.-H., Lee, C.-C., King, C.-C., Chuang, M.-C.*, Ho, J.-a. A.* (2014) Exploitation of stem-loop DNA as a dual-input gene sensing platform: extension to subtyping of influenza A viruses. Chemical Science, 2014, 5, 4082-4090. (SCI) DOI: 10.1039/C4SC01289E
  4. Jou, A. F.-J., Tai, N.-H., Ho, J.-a. A.* (2014) Gold Nanobone/Carbon Nanotube Hybrids for the Efficient Nonenzymatic Detection of H2O2 and Glucose. Electroanalysis, 26, 1816-1823. (SCI) DOI: 10.1002/elan.201400140
  5. Chen, S.-H., Hsu, Y.-Pb, Lu, H.-Y., Ho, J.A.A.* (2014) Gold/Phospholipid nanoconstructs as label-free optical probes for evaluating phospholipase A2 activity. Biosensors and Bioelectronics, 52, 202-208. (SCI) DOI: 10.1016/j.bios.2013.08.017
  6. Liao, W.-C., Ho, J.-a. A.* (2014) Improved activity of immobilized antibody by paratope orientation controller: Probing paratope orientation by electrochemical strategy and surface plasmon resonance spectroscopy. Biosensors and Bioelectronics, 55, 32-38. (SCI) DOI: 10.1016/j.bios.2013.10.054
  1. Chuang, M.-C., Lai, H.-Y., Ho, J.-a. A.*, Chen, Y.-Y. (2013) Multifunctional microelectrode array (mMEA) chip for neural-electrical and neural-chemical interfaces: Characterization of comb interdigitated electrode towards dopamine detection. Biosensors and Bioelectronics, 41, 602–607. DOI: 10.1016/j.bios.2012.09.030
  2. Tien, C.-Y., Jou, A.F.-J., Fan, N.-C., Chuang, M.-C., Ho, J.-A.A.* (2013) Preparation of Liposomal Progesterone and Its Application on the Measurement of Progesterone Interpreted via Electrochemical and Colorimetric Sensing Platforms. Electroanalysis, 25(4), 1017–1022. DOI: 10.1002/elan.201200563
  3. Teng, I.-T., Chang, Y.-J., Wang, L.-S., Lu, H.-Y., Wu, L.-C., Yang, C.-M., Chiu, C.-C., Yang, C.-H., Hsu, S.-L., Ho, J.-a. A.* (2013) Phospholipid-functionalized mesoporous silica nanocarriers forselective photodynamic therapy of cancer. Biomaterials, 34, 7462-7470. DOI: 10.1016/j.biomaterials.2013.06.001
  4. Tanwar, S.,* Ho, J.-a. A., Magi, E. (2013) Green synthesis and characterization of novel gold nanocomposites for electrochemical sensing applications. Talanta, 117, 352-358. DOI:10.1016/j.talanta.2013.09.011
  5. Liao, W.-C., Chuang, M.-C., Ho, J.-a. A.* (2013) Electrochemical sensor for multiplex screening of genetically modified DNA: Identification of biotech crops by logic-based biomolecular analysis. Biosensors and Bioelectronics, 50, 414-420. DOI: 10.1016/j.bios.2013.06.044


  1. Ho, J.-a. A.*, Jou, A. F.J., Wu, L.C., Hsu, S.L. (2012) Development of an immunopredictor for the evaluation of the risk of cardiovascular diseases based on the level of soluble P-selectin. Methods, 56(2), 223-229. (SCI) DOI: 10.1016/j.ymeth.2011.10.014 
  2. Prasad, K. S., Chuang, M.C.,  Ho J.-a. A.* (2011) Synthesis, characterization, and electrochemical applications of carbon nanoparticles derived from castor oil soot. Talanta, 88(15), 445-449. (SCI) DOI:10.1016/j.talanta.2011.10.056 
  3. Ho, J.-a. A.*, Kuo, T.Y., Yu, W.G. (2012) Dual polarization interferometric and capillary electrophoretic analysis of supported lipid bilayer constructed on silica-based surface: Evaluation of its anti-protein adsorption effect. Analytica Chimica Acta, 714(10), 127-133. DOI: 10.1016/j.aca.2011.11.062
  4. Ho, J.-a. A.*, Chang, H.C., Su, W.T. (2012) DOPA-mediated reduction allows the facile synthesis of fluorescent gold nanoclusters for use as sensing probes for ferric Ions. Analytical Chemistry, 82(7), 3246-3253. (SCI) DOI: 10.1021/ac203362g
  5. Chuang, M.C. and Ho, J.-a. A.* (2012) Efficient electrocatalytic oxidation of water: minimization of catalyst loading by an electrostatic assembly of hydrous iridium oxide colloids. RSC Advances, 2, 4092-4096. (SCI) DOI: 10.1039/C2RA00895E
  6. Tanwar, S. Chuang, M.C., Prasad, K.S., Ho, J.-a. A.* (2012) Template-free Synthesis of Electroactive Au-Calix-PPY nanocomposite for Electrochemical Sensor Applications. Green Chemistry, 14, 799-808. (SCI) DOI: 10.1039/C2GC16232F
  7. Prasad, K.S., Fan, N.C., Wi, L.C., Chang, J.C., Wang, L.S., Hwang, K.C., Hwu, J.R., Horng, J.C., Lin, C.C., Ho, J.-a. A.* (2012) A Tunable Multicolor Photoluminescent Nanocarbon Prepared from Castor Oil Soot.  Journal of the Chinese Chemical Society, 59(6), 802–808. (SCI) DOI: 10.1002/jccs.201100626
  8. Fan, N. C., Cheng, F. Y., Ho, J. A.*, Yeh, C. S.* (2012) Photocontrolled Targeted Drug Delivery: Photocaged Biologically Active Folic Acid as a Light-Responsive Tumor-Targeting Molecule. Angew. Chem. Int. Ed., 51(35), 8806-8810. (SCI) DOI: 10.1002/anie.201203339
  9. Ho, J.-a. A.*, Fan, N.C., Jou, A. F.J., Wu, L.C., Sun, T.P., (2012) Monitoring the subcellular localization of doxorubicin in CHO-K1 using MEKC−LIF: Liposomal carrier for enhanced drug delivery. Talanta, 99(15), 683-688. (SCI) DOI: 10.1016/j.talanta.2012.06.077
  10. Freeman, R., Girsh, J., Jou, A. F.J., Ho, J.-a. A., Hug, T., Dernedde, J., Willner, I.*, (2012) Optical Aptasensors for the Analysis of the Vascular Endothelial Growth Factor (VEGF). Anal. Chem., 84(14), 6192–6198.(SCI) DOI: 10.1021/ac3011473
  11. Viswanathana, S.*, Ranib, C., Ho, J.-a. A, (2012) Electrochemical immunosensor for multiplexed detection of food-borne pathogens using nanocrystal bioconjugates and MWCNT screen-printed electrode. Talanta, 94(30), 315–319. (SCI) DOI: 10.1016/j.talanta.2012.03.049
  12. Wang, L.S., Chuang, M.C., Ho, J.-a. A.* (2012) Nanotheranostics – a review of recent publications. Int. J. Nanomedicine, 7, 4679-4695. (SCI) DOI: 10.2147/IJN.S33065


  1. Su, L.C., Chang, Y.F., Chou, C., Ho, J.-a. A., Li, Y.C., Chou, L.D., Lee, C.C. (2011). Binding kinetics of biomolecule interaction at ultralow concentrations based on gold nanoparticle enhancement. Analytical Chemistry, 83(9): 3290-6. (SCI) DOI: 10.1021/ac1028616
  2. Jeng, C.C., Cheng, S.H., Ho, J.-a. A., Huang, S. H.-Y., Chang, J. C., Tsai, P.J., Yang, C.S., Lo, L.W. (2011) Dynamic probing of nanoparticle stability in vivo: a liposomal model assessed using in situ microdialysis and optical imaging. Journal of Nanomaterials, v.2011, 932719. (SCI) DOI:10.1155/2011/932719


  1. Ho, J.-a. A.*, Wu, L.C., Chang, L.H., Hwang, K.C, Hwa, J.-R. R. (2010) Liposome-based immunoaffinity chromatographic assay for the quantitation of immunoglobulin E in human serum. Journal of Chromatography B, 878(2), 172-176. (SCI) DOI: 10.1016/j.jchromb.2009.07.037
  2. Chou, C., Ho, J.-a. A., Chen, C.-C., Ming-Yaw, Liu, W.C., Chang, Y.F., Fu, C., Chen, S.H., Kuo, T.Y. Metal-Enhanced Fluorescence. Geddes, Chris D. (Ed), (2010) Chap 8, John Wiley & Sons press. ISBN: 978-0-470-22838-8  (Book Chapter)

  3. Ho, J.-a. A.*, Chang, H.C., Shih, N.Y.,Wu, L.C., Chang, Y.F., Chen, C.C., Chou, C. (2010) Diagnostic Detection of Human Lung Cancer-Associated Antigen Using a Gold Nanoparticle-Based Electrochemical Immunosensor. Analytical Chemistry, 82 (14), 5944–5950. (SCI) DOI: 10.1021/ac1001959

  4. Wang, L.S., Wu, L.C.*, Lu, S.Y., Chang, L.L., Teng, I.T, Yang, C.M.*, Ho, J.-a. A.* (2010) Biofunctionalized Phospholipid-Capped Mesoporous Silica Nanoshuttles for Targeted Drug Delivery: Improved Water Suspensibility and Decreased Nonspecific Protein Binding. ACS Nano, 4(8), 4371-4379. (SCI) DOI: 10.1021/nn901376h

  5. Chang, I.P, Hwang, K.C., Ho, J.-a. A., Lin, C.C., Hwa, J.-R. R., Horng, J.C. (2010) Facile surface functionalization of nanodiamonds. Langmuir, 26(5), 3685-3689. (SCI) DOI: 10.1021/la903162v

  6. Ho, J.-a. A.*, Hsua, W.L., Liao, W.C., Chiua, J.K., Chen, M.L., Chang, H.C., Lin, C.C. (2010) Ultrasensitive electrochemical detection of biotin using electrically addressable site-oriented antibody immobilization approach via aminophenyl boronic acid. Biosensors and Bioelectronics, 26(3), 1021-1027 (SCI) DOI: 10.1016/j.bios.2010.08.048

  7. Lu, C.L., Prasad K.S., Wu, H.L., Ho, J.-a. A., Huang, Michael H.*, (2010) Au Nanocube-Directed Fabrication of Au−Pd Core−Shell Nanocrystals with Tetrahexahedral, Concave Octahedral, and Octahedral Structures and Their Electrocatalytic Activity.  Journal of American Chemical Society, 132 (41), 14546–14553 (SCI) DOI: 10.1021/ja105401p

  8. Sahabuddina, Sk,Chang T.C., Lin, C.C., Jan F.D., Hsiao, H.Y., Huang, K.T., Chen, J.H. , Horng, J.C.,  Ho, J.-a. A, Lin, C.C.* (2010) Synthesis of N-modified sTn analogs and evaluation of their immunogenicities by microarray-based immunoassay. Tetrahedron, 66(38), 7510-7519 (SCI) DOI:10.1016/j.tet.2010.07.050

  9. Wu L.C., Jou, A. F.J., Chen, S.H., Tien, C.Y., Cheng, C.F., Fan, N.C., Ho, J.-a. A.* (2010) Antioxidant, anti-inflammatory and anti-browning activities of hot water extracts of oriental herbal teas. Food & Function, 1, 200-208 DOI: 10.1039/C0FO00047G

  10. Sourisa, J.S., Lee, C.H., Cheng, S.H., Chen, C.T., Yang, C.S, Ho, J.-a. A., Mou, C.Y., Lo, L.W.*, (2010) Surface Charge-Mediated Rapid Hepatobiliary Excretion of Mesoporous Silica Nanoparticles. Biomaterials, 31(21), 554-5574. DOI: 10.1016/j.biomaterials.2010.03.048


  1. Ho, J.-a. A.*; Lin, Y.C.; Wang, L.S.; Hwang, K.C. and Chou, P.T. (2009). Carbon nanoparticle‐enhanced immunoelectrochemical detection for protein tumor marker with CdS biotracers. Analytical Chemistry, 81(4), 1340-1346. (SCI) DOI: 10.1021/ac801832h
  2. Liao, W. C., Ho, J.-a. A.* (2009). Attomole DNA electrochemical sensor for the detection of Escherichia coli O157Analytical Chemistry, 81(7), 2470-2476. (SCI) DOI: 10.1021/ac8020517
  3. Ho, J.-a A.*, Chiu, J.K., Hsu, W.L., Hong, J.C., Lin, C.C., Hwang, K.C. and Hwu, J.R. (2009). Gold-Nanostructured Immunosensor for the Electrochemical Sensing of Biotin Based on Liposomal Competitive Assay. Journal of Nanoscience and Nanotechnology, 9(4), 2324-2329. (SCI) DOI: 10.1166/jnn.2009.SE40
  4. Viswanathan, S., Rani, C., Vijay Anand, A., Ho, J.-a. A. (2009). Disposable electrochemical immunosensor for carcinoembryonic antigen using ferrocene liposomes and MWCNT screen-printed electrode. Biosensors and Bioelectronics, 24(7), 1984-1989. (SCI) DOI: 10.1016/j.bios.2008.10.006
  5. Wu, L.C.*; Chang, L.H.; Chen, S.H.; Fan, N.C.; Ho, J.-a. A.** (2009). Antioxidant activity and melanogenesis inhibitory effect of the acetonic extract of Osmanthus fragrans: A potential natural and functional food flavor additive. LWT - Food Science and Technology, 42(9), 1513-1519. (SCI) DOI:10.1016/j.lwt.2009.04.004
  6. Chien, H.T., Lee, C.K., Chiu, H.K., Hsu, K.C., Chen, C.C.,* Ho, J.‐a. A., Chou, C. (2009). The Comparison between the Graded Photonic Crystal Coupler and Various Coupler. Journal of Lightwave Technology, 27(14), 2570-2574. (SCI) DOI: 10.1109/JLT.2008.2012271
  7. Ho, J.-a. A.*, Hung, C.H.,Wu, L.C., Liao, M.Y. (2009). Folic acid-anchored PEGgylated phospholipid bioconjugate and its application in a liposomal immunodiagnostic assay for folic acid. Analytical Chemistry, 81(14), 5671-5677. (SCI) DOI: 10.1021/ac900402v
  8. Lin, P.C., Adak, A.K., Ueng. S.H., Huang, L.D., Huang, K.T., Ho, J.-a.A., Lin C.C. (2009) DAST-mediated regioselective anomeric group migration in sacchardies. Journal of Organic Chemistry, 74(11), 4041-4048. (SCI) DOI: 10.1021/jo900516r
  9. Hwu, J.R.*, Huang,  J.-T. J., Tsai, F.Y., Tsay, S.C., Hsu, M.H., Hwang, K.C., Horng, J.C., Ho, J.-a. A, Lin, C.C. (2009). Photochemical Activities of N-Nitroso Carboxamides and Sulfoximides and Their Application to DNA Cleavage, Chemistry - A European Journal, 15(35), 8742 - 8750 (SCI) DOI: 10.1002/chem.200802571


  1. Ho, J-a A.*, Zeng, S.C., Tseng, W.H., Lin, Y.J. and Chen, C.H. (2008). Liposome-Based Immunostrip for the Rapid Detection of Salmonella. Analytical and Bioanalytical Chemistry391(2), 479-485. (SCI) DOI: 10.1007/s00216-008-1875-5

  2. Hsin,Y.L., Lin, C.F., Liang, Y.C., Hwang, K.C., Horng, J.C., Ho, J-a A., Lin, C.C. and Hwu, J.R.(2008). Microwave Arcing Induced Formation and Growth Mechanisms of Core/Shell Metal/Carbon Nanoparticles in Organic Solutions. Advanced Functional Materials, 18(14), 2048-2056. (SCI) DOI: 10.1002/adfm.200701407

  3. Ho, J.-a A.* and Hung, C.H. (2008). Using Liposomal Fluorescent Biolabels To Develop an Immunoaffinity Chromatographic Biosensing System for Biotin. Analytical Chemistry, 80(16), 6405-6409. (SCI) DOI: 10.1021/ac800850w


  1. Wu, L.C. and Ho, J-a A. In Spirulina in Human Nutrition and Health, Gershwin, M.E. and Belay, A. (Eds) (2007). Chap 6 (p119-152), CRC Press, Boca Raton, FL, USA. (Book Chapter)

  2. Subramanian, V., Liao, W.C., Huang, C.C., Hsu, W.L. and Ho, J-a A.* (2007). Rapid Analysis of L-dopa in Urine Samples Using Gold Nanoelectrode Ensembles. Talanta74, 229-234. (SCI) DOI: 10.1016/j.talanta.2007.05.056

  3. Kim, B.Y., Swearingen, C.B., Ho, J-a A., Romanova, E.V., Bohn, P.W. and Sweedler, J.V. (2007). Direct Immobilization of Fab’ in Nanocapillaries for Manipulating Mass-Limited Samples. Journal of American Chemical Society, 129(24), 7620-7626. (SCI) DOI: 10.1021/ja070041w

  4. Ho, J-a A.*, Wu, L.C., Huang, M.R., Lin, Y.J., Baeumner, A.J. and Durst, R.A. (2007). Application of Ganglioside-sensitized Liposomes in a Flow-Injection Immunoanalytical System for the Determination of Cholera Toxin. Analytical Chemistry, 79(1), 246-250. (SCI) DOI: 10.1021/ac060889n

  5. Subramanian, V. and Ho, J-a A.* (2007). Dual Electrochemical Determination of Glucose and Insulin Using Enzyme and Ferrocene Microcapsules. Biosensors and Bioelectronics, 22(6), 1147-1153. (SCI) DOI: 10.1016/j.bios.2006.07.031

  6. Ho, J-a A.*, Wu, L.C, Fan, N.C., Lee, M.S., Kuo, H.Y. and Yang, C.S. (2007). Development of a Long-life Capillary Enzyme Bioreactor for the Determination of Blood Glucose. Talanta, 71, 391-396. (SCI) DOI: 10.1016/j.talanta.2006.04.023


  1. Subramanian, V., Wu, L.C., Huang, M.R. and Ho, J-a A.* (2006). Electrochemical Immunosensor for Cholera Toxin Using Liposomes and poly(3,4-ethylenedioxythiophene)- Coated Carbon Nanotubes. Analytical Chemistry, 78(4), 1115-1121. (SCI) DOI: 10.1021/ac051435d

  2. Ho, J-a A.*, Zeng, S.C., Huang, M.R. and Kuo, H.Y. (2006). Development of Liposomal Immunosensor for the Measurement of Insulin with Femtomole Detection. Analytica Chimica Acta, 556, 127-132. (SCI) DOI: 10.1016/j.aca.2005.08.074

  3. Wu, L.C.*, Hsu, H.W., Chen, Y.C., Chiu, C.C., Chang, C.W., Lin, Y.Y. and Ho, J-a A.* (2006). Antioxidant and Antiproliferative Activities of Red Pitaya. Food Chemistry, 95, 319-327. (SCI) DOI: 10.1016/j.foodchem.2005.01.002

  4. Ho, J-a A.*, Kuo, H.Y., Wang, Y.T. and Yang, C.S. (2006). Occurrence of Aristolochic Acids in Over-the-Counter Chinese Prepared Medicines. Asian Journal of Chemistry, 18(1)253-258. (SCI)


  1. Ho, J-a A.* and Huang, M.R. (2005). Application of Liposomal Bioluminescent Label in the Development of Flow Injection Immunoanalytical System. Analytical Chemistry, 77(11), 3431-3436. (SCI) DOI: 10.1021/ac0484474

  2. Wu, L.C., Ho, J-a A., Shieh, M.C. and Lu, I.W. (2005). Antioxidant and Antiproliferative Activities of Spirulina and Chlorella Water Extracts. Journal of Agricultural and Food Chemistry, 53(10), 4207-4212. (SCI) DOI: 10.1021/jf0479517


  1. Lo, L.W., Ho, J-a A, Chang, Y.H., Chang, C.H, Yang, C.S. (2004). Potential Usage of Liposome-encapulated Phosphor for in vivo Imaging of Tissue Oxygenation. Biomedical Engineering Applications, Basis and Communications. 16(4), 224-229. (EI)
  2. Ho, J-a A.,* Hsu, H.W. and Huang, M.R. (2004). Liposome-based Microcapillary Immunosensor for Detection of Escherichia coli O157:H7. Analytical Biochemistry. 330:342-349. (SCI) DOI: 10.1016/j.ab.2004.03.038


  1. Ho, J-a A.* and Hsu, H.W. (2003). Procedures for Preparing Escherichia coli O157:H7 Immunoliposome and Its Application in Liposome Immunoassay. Analytical Chemistry. 75:4330-4334. (SCI) DOI: 10.1021/ac0343580

  2. Wu, L.C., Chen, Y.C., Ho, J-a A. and Yang, C.S. (2003). Inhibitory Effect of Red Koji Extracts on Mushroom Tyrosinase. Journal of Agricultural and Food Chemistry. 51: 4240-4246. (SCI) DOI: 10.1021/jf034064f
  3. Ho, J-a A.* and Durst, R.A. (2003). Detection of Fumonisin B1: Comparison of Flow-injection Liposome Immunoanalysis with High-performance Liquid Chromatography. Analytical Biochemistry. 312:7-13. (SCI) DOI: 10.1016/S0003-2697(02)00393-7


  1. Ho, J-a A.* and Wauchope, R.D. (2002). A rapid strip liposome immunoassay for aflatoxin B1. Analytical Chemistry. 74:1493-1496. (SCI) DOI: 10.1021/ac010903q
  2. Ho, J-a A., Yang, C.S. and Tzeng, H.F. (2001). Overview of capillary electrochromatography. 化學. 59(3):399-408.
  3. Ho, J-a A.* and Durst, R.A. (2000). Preparation of reagents for the determination of fumonisin B1 by flow-injection immunoanalyis. Analytica Chimica Acta. 414:51-60. (SCI) DOI: 10.1016/S0003-2670(00)00782-0
  4. Ho, J-a A.* and Durst, R.A. (2000). Development of a flow-injection liposome immunoanalytical (FILIA) system for fumonisin B1. Analytica Chimica Acta. 414:61-69. (SCI) DOI: 10.1016/S0003-2670(00)00786-8

Courses Taught