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Tzu-Ming Pan
Professor Emeritus,Adjunct Professor,Retired Professors
Job Title Professor Emeritus
Name Tzu-Ming Pan
Office Tel No. 02-3366-4519
Email tmpan@ntu.edu.tw
Education Doctor, Dept. Agric Chem.,National Taiwan University(1972/09 ~ 1978/06)
Research Expertise Biotechnology, Applied Microbiology, Functional Food
Teaching Field Genetically Modified Food, Functional Food, Food Biotechnology, Microbiology and Immunology
Location Applied Microbiology and Biotechnology Laboratory(AC-105)
Tel(Lab) +886-2-3366-4519#10
Fax +886-2-3366-3838
Lab Website http://panlab.bst.ntu.edu.tw/
  • Doctor, Dept. Agric Chem, National Taiwan University(1972/09 ~ 1978/06)
  • Master, Dept Agric Chem, National Taiwan University(1970/09 ~ 0972/06)
  • Bachelor, Dept Agric Chem, National Taiwan University(1965/09 ~ 1969/06)
  • Professor, Dept Biochem Sci Tech (BST)(2003/08 ~ 2016/01)
  • Director, Dept Biochem Sci Tech (BST)(2009/08 ~ 2012/07)
  • Professor and Director, Institute Microbiol Biochem (mbc)(2003/08 ~ 2009/07)
  • Professor, Dept Agric Chem(1998/09 ~ 2003/08)
  • Director, Institute of National Prevention Medicine(1993/08 ~ 1998/09)
  • Professor and Director, Dept Applied Chem, Chinese Culture Univ(1986/08 ~ 1993/08)
  • Professor, Dept Applied Chem, Chinese Culture Univ(1981/08 ~ 1986/08)
  • Associate Professor, Dept Applied Chem, Chinese Culture Univ(1978/08 ~ 1981/08)
  • IFT Fellows, The Institute of Food Technologists (IFT)(2012)
  • University Award, Distinguished Professor, NTU(2009)
  • Research Award, Outstanding Research Award from National Science Council, ROC (2009)
  • Research Award, Outstanding Research Award from Health Food Society of Taiwan(2004)
  • Research Award, Outstanding Research Award from Taiwan Institute of Food Technology(2004)
  • Research Award, Outstanding Research Award from Biotaiwan(2004)
  • Research Award, Outstanding Research Award from Association of Microbiology ROC(2003)
  • Teaching Award, Outstanding Teacher from Department of Education(1989)
  • Research Award, Outstanding Youth, ROC(1978)

Research Focus

Part 1:  Research topics related to red mold fermented products:
    Monascus-fermented products have been used in food, medicine, and industry dates back over a thousand years in Asia countries. Monascus-fermented products contained several bioactive metabolites such as the pigments, polyketide monacolins, dimerumic acid, and γ-aminobutyric acid. Scientific reports showed that Monascus-fermented products proved to be effective for the management of blood cholesterol, diabetes, blood pressure, obesity, Alzheimer’s disease and prevention of cancer development. Those are our research points related to red mold fermented products.
 
Part 2:  Research topics related to lactic acid bacteria:
    Lactic acid bacteria have showed to possess antimutagenic, anticarcinogenic, and hypocholesterolemic properties. Further, they were also observed to have antagonistic actions against intestinal and food-borne pathogens, to decrease the prevalence of allergies in susceptible individuals, and to have immunomodulatory effects. Typically, the bacteria colonise the intestinal tract first and then reinforce the host defense systems by inducing a generalised mucosal immune response, balanced T-helper cell response, self-limited inflammatory response, and secretion of polymeric IgA. Scientific reports showed that the Taiwan native lactic acid bacterium from newborn infant feces identified as Lactobacillus paracasei subsp. paracasei NTU 101 and its’fermented products proved to be effective for the management of blood cholesterol and pressure, prevention of gastric mucosal lesion development, immunomodulation and alleviation of allergies, anti-osteoporosis and inhibition the fat tissue accumulation. Those are our research points related to lactic acid bacteria.
2018
  1. Liu, TH, Tsai, TY, Pan, TM. Effects of an ethanol extract from Lactobacillus paracasei subsp. paracasei NTU 101 fermented skimmed milk on lipopolysaccharide-induced periodontal inflammation in rats. Food Funct 2018; 9(9): 4916-25.(SCI)
  2. Lin, CH, Shih, TW, Pan, TM. A "Ct contrast"-based strain-specific real-time quantitative PCR system for Lactobacilllus paracasei subsp. paracasei NTU 101. J Microbiol Immunol Infect 2018; 51(4): 535-44.(SCI)
  3. Chang, CY, Pan, TM. Anticancer and Antimigration Effects of a Combinatorial Treatment of 5-Fluorouracil and Lactobacillus paracasei subsp. paracasei NTU 101 Fermented Skim Milk Extracts on Colorectal Cancer Cells. J Agric Food Chem 2018; 66(22): 5549-55.(SCI)
  4. Liu, TH, Tsai, TY, Pan, TM. The Anti-Periodontitis Effects of Ethanol Extract Prepared Using Lactobacillus paracasei subsp. paracasei NTU 101. Nutrients 2018; 10(4).(SCI)
  5. Cheng, CF, Pan, TM. Monascus-fermented red mold dioscorea protects mice against alcohol-induced liver injury, whereas its metabolites ankaflavin and monascin regulate ethanol-induced peroxisome proliferator-activated receptor-gamma and sterol regulatory element-binding transcription factor-1 expression in HepG2 cells. J Sci Food Agric 2018; 98(5): 1889-98.(SCI)
  6. Lee, CL, Wen, JY, Hsu, YW, Pan, TM. The blood lipid regulation of Monascus-produced monascin and ankaflavin via the suppression of low-density lipoprotein cholesterol assembly and stimulation of apolipoprotein A1 expression in the liver. J Microbiol Immunol Infect 2018; 51(1): 27-37.(SCI)
  7. Wang, LC, Pan, TM, Tsai, TY. Lactic acid bacteria-fermented product of green tea and Houttuynia cordata leaves exerts anti-adipogenic and anti-obesity effects. J Food Drug Anal 2018; 26(3): 973-84.(SCI)
  8. Liu, SF, Wang, YR, Shen, YC, Chen, CL, Huang, CN, Pan, TM, Wang, CK. A randomized, double-blind clinical study of the effects of Ankascin 568 plus on blood lipid regulation. J Food Drug Anal 2018; 26(1): 393-400.(SCI)
  9. Lin, TH, Lin, CH, Pan, TM. The implication of probiotics in the prevention of dental caries. Appl Microbiol Biotechnol 2018; 102(2): 577-86.(SCI)

2017
  1. Cheng, MC, Pan, TM. Glyceryl 1,3-Dipalmitate Produced from Lactobacillus paracasei subspecies. paracasei NTU 101 Inhibits Oxygen-Glucose Deprivation and Reperfusion-Induced Oxidative Stress via Upregulation of Peroxisome Proliferator-Activated Receptor gamma in Neuronal SH-SY5Y Cells. J Agric Food Chem 2017; 65(36): 7926-33.(SCI)
  2. Hu, MJ, Liu, GY, Yang, Y, Pan, TM, Liu, YX, Sun, LC, Cao, MJ, Liu, GM. Cloning, Expression, and the Effects of Processing on Sarcoplasmic-Calcium-Binding Protein: An Important Allergen in Mud Crab. J Agric Food Chem 2017; 65(30): 6247-57.(SCI)
  3. Wang, YR, Liu, SF, Shen, YC, Chen, CL, Huang, CN, Pan, TM, Wang, CK. A randomized, double-blind clinical study to determine the effect of ANKASCIN 568 plus on blood glucose regulation. J Food Drug Anal 2017; 25(2): 409-16.(SCI)
  4. Lin, CH, Lin, TH, Pan, TM. Alleviation of metabolic syndrome by monascin and ankaflavin: the perspective of Monascus functional foods. Food Funct 2017; 8(6): 2102-9.(SCI)
  5. Lee, CL, Pan, TM. The Prevention of Alzheimer's Disease and Parkinson’s Disease by Monascus purpureus NTU 568-Fermented Compounds. J Alzheimers Dis Parkinsonism 2017; 7(4): 1000342.
  6. Lin, CH, Chen, YH, Tsai, TY, Pan, TM. Effects of deep sea water and Lactobacillus paracasei subsp. paracasei NTU 101 on hypercholesterolemia hamsters gut microbiota. Appl Microbiol Biotechnol 2017; 101(1): 321-9.(SCI)
  7. Chen, CL, Tseng, JH, Pan, TM, Hsiao, SH. A Randomized, Double-Blind Clinical Study on Blood Pressure Reduction and Blood Lipid Profile Amelioration on Treatment with Ankascin 568. Chin J Physiol 2017; 60(3): 158-65.(SCI)
  8. Cheng, MC, Pan, TM. Prevention of hypertension-induced vascular dementia by Lactobacillus paracasei subsp. paracasei NTU 101-fermented products. Pharm Biol 2017; 55(1): 487-96.(SCI)
2016
  1. Cheng CF, Pan TM. Ankaflavin and Monascin Induce Apoptosis in Activated Hepatic Stellate Cells through Suppression of the Akt/NF-kappaB/p38 Signaling Pathway. J Agric Food Chem. 2016; 64(49): 9326-34.(SCI)
  2. Chen, CL, Tsai, WH, Chen, CJ, Pan, TM. Centella asiatica extract protects against amyloid beta1-40-induced neurotoxicity in neuronal cells by activating the antioxidative defence system. J Tradi Comple Medicine 2016; 6(4): 362-9.
  3. Shi, YC, Pan, TM, Liao, VH. Monascin from Monascus-Fermented Products Reduces Oxidative Stress and Amyloid-beta Toxicity via DAF-16/FOXO in Caenorhabditis elegans. J Agric Food Chem. 2016; 64(38): 7114-20.(SCI)
  4. Cheng, MC, Leu, YL, Tsai, TY, Pan, TM. Screening and identification of neuroprotective compounds produced by Lactobacillus paracasei subsp. paracasei NTU 101. J Fun Food. 2016; 26: 238-48.(SCI)
  5. Tseng, WT, Hsu, YW, Pan, TM. Dimerumic Acid and Deferricoprogen Activate Ak Mouse Strain Thymoma/Heme Oxygenase-1 Pathways and Prevent Apoptotic Cell Death in 6-Hydroxydopamine-Induced SH-SY5Y Cells. J Agric Food Chem. 2016; 64(30): 5995-6002.(SCI)
  6. Tseng, WT, Hsu, YW, Pan, TM. Neuroprotective effects of dimerumic acid and deferricoprogen from Monascus purpureus NTU 568-fermented rice against 6-hydroxydopamine-induced oxidative stress and apoptosis in differentiated pheochromocytoma PC-12 cells. Pharm Biol. 2016; on line.(SCI)
  7. Hung, SC, Tseng, WT, Pan, TM. Lactobacillus paracasei subsp. paracasei NTU 101 ameliorates impaired glucose tolerance induced by a high-fat, high-fructose diet in Sprague-Dawley rats. J Fun Food. 2016; 24: 472-81.(SCI)
  8. Tseng, WT, Hsu, YW, Pan, TM. The ameliorative effect of Monascus purpureus NTU 568-fermented rice extracts on 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells and the rat model of Parkinson's disease. Food Funct. 2016; 7(2): 752-62.(SCI)
  9. Lin, CH, Pan, TM. Perspectives on genetically modified crops and food detection. J Food Drug Anal. 2016; 24(1): 1-8.(SCI)
  10. Chen, CL, Chang, KY, Pan, TM. Monascus purpureus NTU 568 fermented product improves memory and learning ability in rats with aluminium-induced Alzheimer's disease. J Fun Food. 2016; 21: 167-77.(SCI)
2015
  1. Huang DH, Wang K, Chiu CP, Pan TM, Tsai TY. Effects of chemical and low-temperature treatments and adaption on the responses of virulence factor genes and outer membrane proteins in Escherichia coli O157:H7. J Microbiol Immunol Infect 2015; 48(6): 604-12.(SCI)
  2. Hsu WH, Lee BH, Pan TM. Leptin-induced mitochondrial fusion mediates hepatic lipid accumulation. Int J Obes (Lond) 2015; 39(12): 1750-6.(SCI)
  3. Chen CL, Pan TM. Effects of red mold dioscorea with pioglitazone, a potentially functional food, in the treatment of diabetes. J Food Drug Anal 2015; 23(4): 719-28.(SCI)
  4. Cheng MC, Tsai TY, Pan TM. Anti-obesity activity of the water extract of Lactobacillus paracasei subsp. paracasei NTU 101 fermented soy milk products. Food Funct 2015; 6(11): 3522-30.(SCI)
  5. Lin TH, Pan TM. Optimization of antimicrobial substances produced from Lactobacillus paracasei subsp. paracasei NTU 101 (DSM 28047) and Lactobacillus plantarum NTU 102 by response surface methodology. J Food Sci Technol 2015; 52(9): 6010-6.(SCI)
  6. Lee CL, Lin PY, Hsu YW, Pan TM. Monascus-fermented monascin and ankaflavin improve the memory and learning ability in amyloid β-protein intracerebroventricular-infused rat via the suppression of Alzheimer's disease risk factors. J Funct Foods 2015; 18, Part A: 387-99.(SCI)
  7. Chen XF, Lin JW, Pan TM, Cao MJ, Shi CL, Cai QF, Liu GM. Investigation of the hazardous substance causing crayfish-induced rhabdomyolysis via a mouse model, a hemolysis assay, and a cytotoxicity assay. Fish Sci 2015; 81(3): 551-8.(SCI)
  8. Liu Qm, Wang Yh, Cao Mj, Pan Tm, Yang Y, Mao Hy, Sun Lc, Liu Gm. Anti-allergic activity of R-phycocyanin from Porphyra haitanensis in antigen-sensitized mice and mast cells. Int Immunopharmacol 2015; 25(2): 465-73.(SCI)
  9. Chang YY, Hsu WH, Pan TM. Monascus secondary metabolites monascin and ankaflavin inhibit activation of RBL-2H3 cells. J Agric Food Chem 2015; 63(1): 192-9.(SCI)
  10. Shi CL, Pan TM, Cao MJ, Liu QM, Zhang LJ, Liu GM. Suppression of Th2 immune responses by the sulfated polysaccharide from Porphyra haitanensis in tropomyosin-sensitized mice. Int Immunopharmacol 2015; 24(2): 211-8.(SCI)
  11. Tseng WT, Shih TW, Liu SH, Pan TM. Safety and mutagenicity evaluation of Vigiis 101 powder made from Lactobacillus paracasei subsp. paracasei NTU 101. Regul Toxicol Pharmacol 2015; 71(2): 148-57.(SCI)
2014
  1. Lin SH, Chen WC, Lu KH, Chen PJ, Hsieh SC, Pan TM, Chen ST, Sheen LY. Down-regulation of Slit-Robo pathway mediating neuronal cytoskeletal remodeling processes facilitates the antidepressive-like activity of Gastrodia elata Blume. J Agric Food Chem 2014; 62(43): 10493-503.(SCI)
  2. Tan YY, Hsu WH, Shih TW, Lin CH, Pan TM. Proteomic insight into the effect of ethanol on citrinin biosynthesis pathway in Monascus purpureus NTU 568. Food Res Int 2014; 64(0): 733-42.(SCI)
  3. Hsu LC, Hsu YW, Hong CC, Pan TM. Safety and mutagenicity evaluation of red mold dioscorea fermented from Monascus purpureus NTU 568. Food Chem Toxicol 2014; 67(0): 161-8.(SCI)
  4. Tsai YT, Cheng PC, Pan TM. Anti-obesity effects of gut microbiota are associated with lactic acid bacteria. Appl Microbiol Biotechnol 2014; 98(1): 1-10.(SCI)
  5. Tsai TY, Chen LY, Pan TM. Effect of probiotic-fermented, genetically modified soy milk on hypercholesterolemia in hamsters. J Microbiol Immunol Infect 2014; 47(1): 1-8.(SCI)
  6. Hsu WH, Chen TH, Lee BH, Hsu YW, Pan TM. Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. Food Chem Toxicol 2014; 64(0): 94-103.(SCI)
  7. Lin TH, Pan TM. Inhibitory effect of Lactobacillus paracasei subsp. paracasei NTU 101 on rat dental caries. J Funct Foods 2014; 10(0): 223-31.(SCI)
  8. Hsu WH, Pan TM. A novel PPARgamma agonist monascin's potential application in diabetes prevention. Food Funct 2014; 5(7): 1334-40.(SCI)
  9. Hsu WH, Pan TM. Treatment of metabolic syndrome with ankaflavin, a secondary metabolite isolated from the edible fungus Monascus spp. Appl Microbiol Biotechnol 2014; 98(11): 4853-63.(SCI)
  10. Hsu WH, Lee BH, Pan TM. Monascin Attenuates Oxidative Stress-Mediated Lung Inflammation via Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-gamma) and Nuclear Factor-Erythroid 2 Related Factor 2 (Nrf-2) Modulation. J Agric Food Chem 2014; 62(23): 5337-44.(SCI)
  11. Balakrishnan B, Chen CC, Pan TM, Kwon HJ. Mpp7 controls regioselective Knoevenagel condensation during the biosynthesis of Monascus azaphilone pigments. Tetrahedron Lett 2014; 55(9): 1640-3.(SCI)
 2013
  1. Hsu WH, Lu SS, Lee BH, Hsu YW, Pan TM. Monacolin K and monascin attenuated pancreas impairment and hyperglycemia induced by advanced glycation endproducts in BALB/c mice. Food Funct 2013; 4(12): 1742-50.(SCI)
  2. Wang LC, Lung TY, Kung YH, Wang JJ, Tsai TY, Wei BL, Pan TM, Lee CL. Enhanced anti-obesity activities of red mold dioscorea when fermented using deep ocean water as the culture water. Mar Drugs 2013; 11(10): 3902-25.(SCI)
  3. Hsu WH, Lee BH, Chang YY, Hsu YW, Pan TM. A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia. Toxicol Appl Pharmacol 2013; 272(3): 842-51.(SCI)
  4. Lee BH, Hsu WH, Hsu YW, Pan TM. Suppression of dimerumic acid on hepatic fibrosis caused from carboxymethyl-lysine (CML) by attenuating oxidative stress depends on Nrf2 activation in hepatic stellate cells (HSCs). Food Chem Toxicol 2013; 62(0): 413-9.(SCI)
  5. Hsu WH, Lee BH, Hsu YW, Pan TM. Inhibition of Th2 Cytokine Production in T Cells by Monascin via PPAR-gamma Activation. J Agric Food Chem 2013; 61(34): 8126-33.(SCI)
  6. Hsu WH, Lee BH, Hsu YW, Pan TM. Peroxisome proliferator-activated receptor-gamma activators monascin and rosiglitazone attenuate carboxymethyllysine-induced fibrosis in hepatic stellate cells through regulating the oxidative stress pathway but independent of the receptor for advanced glycation end products signaling. J Agric Food Chem 2013; 61(28): 6873-9.(SCI)
  7. Chen CL, Pan TM. Red mold dioscorea decreases blood pressure when administered alone or with amlodipine and is a potentially safe functional food in SHR and WKY rats. J Funct Foods 2013; 5(3): 1456-65.(SCI)
  8. Hsu WH, Lee BH, Li CH, Hsu YW, Pan TM. Monascin and AITC Attenuate Methylglyoxal-Induced PPARγ Phosphorylation and Degradation through Inhibition of the Oxidative Stress/PKC Pathway Depending on Nrf2 Activation. J Agric Food Chem 2013; 61(25): 5996-6006.(SCI)
  9. Lee BH, Hsu WH, Huang T, Chang YY, Hsu YW, Pan TM. Monascin improves diabetes and dyslipidemia by regulating PPARgamma and inhibiting lipogenesis in fructose-rich diet-induced C57BL/6 mice. Food Funct 2013; 4(6): 950-9.(SCI)
  10. Lee BH, Lo YH, Pan TM. Anti-obesity activity of Lactobacillus fermented soy milk products. J Funct Foods 2013; 5(2): 905-13.(SCI)
  11. Lee BH, Hsu WH, Hsu YW, Pan TM. Dimerumic acid protects pancreas damage and elevates insulin production in methylglyoxal-treated pancreatic RINm5F cells. J Funct Foods 2013; 5(2): 642-50.(SCI)
  12. Hsu LC, Liang YH, Hsu YW, Kuo YH, Pan TM. Anti-inflammatory Properties of Yellow and Orange Pigments from Monascus purpureus NTU 568. J Agric Food Chem 2013; 61(11): 2796-802.(SCI)
  13. Lee BH, Hsu WH, Hsu YW, Pan TM. Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into D-lactic acid. Free Radic Biol Med 2013; 60(1): 7-16.(SCI)
  14. Lee CL, Wen JY, Hsu YW, Pan TM. Monascus-Fermented Yellow Pigments Monascin and Ankaflavin Showed Antiobesity Effect via the Suppression of Differentiation and Lipogenesis in Obese Rats Fed a High-Fat Diet. J Agric Food Chem 2013; 61(7): 1493-500.(SCI)
  15. Lee BH, Hsu WH, Huang T, Chang YY, Hsu YW, Pan TM. Effects of Monascin on Anti-inflammation Mediated by Nrf2 Activation in Advanced Glycation End Product-Treated THP-1 Monocytes and Methylglyoxal-Treated Wistar Rats. J Agric Food Chem 2013; 61(6): 1288-98.(SCI)
  16. Lee BH, Pan TM. Dimerumic acid, a novel antioxidant identified from Monascus-fermented products exerts chemoprotective effects: Mini review. J Funct Foods 2013; 5(1): 2-9.(SCI)
  17. Hsu WH, Liao TH, Lee BH, Hsu YW, Pan TM. Ankaflavin regulates adipocyte function and attenuates hyperglycemia caused by high-fat diet via PPAR-γ activation. J Funct Foods 2013; 5(1): 124-32.(SCI)
  18. Hsu WH, Huang YC, Lee BH, Hsu YW, Pan TM. The improvements of ankaflavin isolated from Monascus-fermented products on dyslipidemia in high-fat diet-induced hasmster. J Funct Foods 2013; 5(1): 434-43.(SCI)
  19. Chen YM, Shih TW, Chiu CP, Pan TM, Tsai TY. Effects of lactic acid bacteria-fermented soy milk on melanogenesis in B16F0 melanocytes. J Funct Foods 2013; 5(1): 395-405.(SCI)
  20. Chiang SS, Pan TM. Beneficial effects of phytoestrogens and their metabolites produced by intestinal microflora on bone health. Appl Microbiol Biotechnol 2013; 97(4): 1489-500.(SCI)
  21. Lee CL, Hung YP, Hsu YW, Pan TM. Monascin and Ankaflavin Have More Anti-atherosclerosis Effect and Less Side Effect Involving Increasing Creatinine Phosphokinase Activity than Monacolin K under the Same Dosages. J Agric Food Chem 2013; 61(1): 143-50.(SCI)
 2012
  1. Wang LC, Wang SE, Wang JJ, Tsai TY, Lin CH, Pan TM, Lee CL. In vitro and in vivo comparisons of the effects of the fruiting body and mycelium of Antrodia camphorata against amyloid beta-protein-induced neurotoxicity and memory impairment. Appl Microbiol Biotechnol. 2012; 94(6): 1505-19. (SCI)
  2. Lee BH, Hsu WH, Chang YY, Kuo HF, Hsu YW, Pan TM. Ankaflavin: a natural novel PPARgamma agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. Free Radic Biol Med. 2012; 53(11): 2008-16. (SCI)
  3. Tsai YT, Cheng PC, Pan TM. The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits. Appl Microbiol Biotechnol. 2012; 96(4): 853-62. (SCI)
  4. Hsu WH, Lee BH, Huang YC, Hsu YW, Pan TM. Ankaflavin, a novel Nrf-2 activator for attenuating allergic airway inflammation. Free Radic Biol Med. 2012; 53(9): 1643-51. (SCI)
  5. Hsu LC, Hsu YW, Liang YH, Lin ZH, Kuo YH, Pan TM. Protective effect of deferricoprogen isolated from Monascus purpureus NTU 568 on citrinin-induced apoptosis in HEK-293 cells. J Agric Food Chem. 2012; 60(32): 7880-5. (SCI)
  6. Lee BH, Hsu WH, Liao TH, Pan TM. Inhibition of leukemia proliferation by a novel polysaccharide identified from Monascus-fermented dioscorea via inducing differentiation. Food Funct. 2012; 3(7): 758-64. (SCI)
  7. Huang CC, Ho BY, Pan TM. Modulation of Proinflammatory Cytokines by Red Mold Dioscorea Ethanol Extract in Radioactive Cobalt-60 Exposure. J Food Drug Analysis. 2012; 20(2): 516-23. (SCI)
  8. Shi YC, Yu CW, Liao VH, Pan TM. Monascus-Fermented Dioscorea Enhances Oxidative Stress Resistance via DAF-16/FOXO in Caenorhabditis elegansPLoS One. 2012; 7(6): e39515. (SCI)
  9. Tsai TY, Dai RY, Tsai WL, Sun YC, Pan TM. Effect of Fermented Milk Produced by Lactobacillus paracasei subsp. paracasei NTU 101 on Blood Lipid. Taiwanese J Agric Chem & Food Sci. 2012; 50(1): 33-40.
  10. Lee CL, Pan TM. Development of Monascus fermentation technology for high hypolipidemic effect. Appl Microbiol Biotechnol. 2012; 94(6): 1449-59. (SCI)
  11. Lee BH, Pan TM. Benefit of Monascus-fermented products for hypertension prevention: a review. Appl Microbiol Biotechnol. 2012; 94(5): 1151-61. (SCI)
  12. Chiang SS, Liu CF, Tseng KC, Mau JL, Pan TM. Immunomodulatory effects of dead Lactobacillus on murine splenocytes and macrophages. Food Agric Immunol. 2012; 23(2): 183-202. (SCI)
  13. Chen CL, Pan TM. Red mold dioscorea: A potentially safe traditional function food for the treatment of hyperlipidemia. Food Chem. 2012; 134(2): 1074-80. (SCI)
  14. Tseng KC, Fang TJ, Chiang SS, Liu CF, Wu CL, Pan TM. Immunomodulatory activities and antioxidant properties of polysaccharides from Monascus-fermented products in vitro. J Sci Food Agric. 2012; 92(7): 1483-9.(SCI)
  15. Hsu WH, Pan TM. Monascus purpureus-fermented products and oral cancer: a review. Appl Microbiol Biotechnol. 2012; 93(5): 1831-42. (SCI)
  16. Shi YC, Pan TM. Red mold, diabetes, and oxidative stress: a review. Appl Microbiol Biotechnol. 2012; 94(1): 47-55.(SCI)
  17. Hsu WH, Lee BH, Liao TH, Hsu YW, Pan TM. Monascus-fermented metabolite monascin suppresses inflammation via PPAR-gamma regulation and JNK inactivation in THP-1 monocytes. Food Chem Toxicol. 2012; 50(5): 1178-86.(SCI)
  18. Hsu WH, Lee BH, Lu IJ, Pan TM. Ankaflavin and Monascin Regulate Endothelial Adhesion Molecules and Endothelial NO Synthase (eNOS) Expression Induced by Tumor Necrosis Factor-alpha (TNF-alpha) in Human Umbilical Vein Endothelial Cells (HUVECs). J Agric Food Chem. 2012; 60(7): 1666-72.(SCI)
  19. Lee BH, Hsu WH, Pan TM. Red mold rice against hepatic inflammatory damage in Zn-deficient rats. J Tradit Complement Med. 2012; 2(1): 52-60
  20. Chiang SS, Pan TM. Beneficial effects of Lactobacillus paracasei subsp. paracasei NTU 101 and its fermented products. Appl Microbiol Biotechnol. 2012; 93(3): 903-16.(SCI).
  21. Hsu LC, Hsu YW, Liang YH, Liaw CC, Kuo YH, Pan TM. Induction of Apoptosis in Human Breast Adenocarcinoma Cells MCF-7 by Monapurpyridine A, a New Azaphilone Derivative from Monascus purpureus NTU 568. Molecules. 2012; 17(1): 664-73.(SCI).
  22. Shi YC, Liao VH, Pan TM. Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegansFree Radic Biol Med. 2012; 52(1): 109-17.(SCI).
  23. Chiang SS, Liao JW, Pan TM. Effect of bioactive compounds in Lactobacilli-fermented soy skim milk on femoral bone microstructure of aging mice. J Sci Food Agric. 2012; 92(2): 328-35.(SCI).
 2011
  1. Lin CH, Chen YC, Pan TM. Quantification bias caused by plasmid DNA conformation in quantitative real-time PCR assay. PLoS One. 2011; 6(12): e29101.(SCI).
  2. Huang T, Hsu WH, Chang YY, Pan TM. The anti-inflammatory effect of the Monascus-fermented product monascin on murine macrophages. Taiwanese J Agric Chem & Food Sci. 2011; 49(3): 111-7
  3. Tung YT, Lee BH, Liu CF, Pan TM. Optimization of Culture Condition for ACEI and GABA Production by Lactic Acid Bacteria. J Food Sci. 2011; 76(9): M585-M91.(SCI).
  4. Cheng CF, Pan TM. Protective effect of Monascus-fermented red mold rice against alcoholic liver disease by attenuating oxidative stress, inflammatory response. J Agric Food Chem. 2011; 59(18): 9950-7.(SCI).
  5. Shih TW, Pan TM. Substitution of Asp189 residue alters the activity and thermostability of Geobacillus sp. NTU 03 lipase. Biotechnol Lett. 2011; 33(9): 1841-6.(SCI).
  6. Lee CL, Kung YH, Wang JJ, Lung TY, Pan TM. Enhanced hypolipidemic effect and safety of red mold dioscorea cultured in deep ocean water. J Agric Food Chem. 2011; 59(15): 8199-207.(SCI).
  7. Chiang SS, Chang SP, Pan TM. Osteoprotective effect of Monascus-fermented dioscorea in ovariectomized rat model of postmenopausal osteoporosis. J Agric Food Chem. 2011; 59(17): 9150-7.(SCI).
  8. Lee CL, Pan TM. Red mold fermented products and Alzheimer's disease: a review. Appl Microbiol Biotechnol. 2011; 91(3): 461-9.(SCI).
  9. Chiang SS, Pan TM. Antiosteoporotic effects of Lactobacillus -fermented soy skim milk on bone mineral density and the microstructure of femoral bone in ovariectomized mice. J Agric Food Chem. 2011; 59(14): 7734-42.(SCI).
  10. Tsai RL, Ho BY, Pan TM. Red mold rice mitigates oral carcinogenesis in 7,12-dimethyl-1,2-benz[a]anthracene-Induced oral carcinogenesis in hamster. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011: Article ID 245209, 8 pages, doi:10.1093/ecam/nep215.(SCI).
  11. Shih TW, Pan TM. Stress responses of thermophilic Geobacillus sp. NTU 03 caused by heat and heat-induced stress. Microbiol Res. 2011; 166(5): 346-59.(SCI).
  12. Ho BY, Wu YM, Chang KJ, Pan TM. Dimerumic acid inhibits SW620 cell invasion by attenuating H2O2-mediated MMP-7 expression via JNK/C-Jun and ERK/C-Fos activation in an AP-1-dependent manner. Int J Biol Sci. 2011; 7(6): 869–80.(SCI).
  13. Lee BH, Hsu WH, Liao TH, Pan TM. The Monascus metabolite monascin against TNF-alpha-induced insulin resistance via suppressing PPAR-gamma phosphorylation in C2C12 myotubes. Food Chem Toxicol. 2011; 49(10): 2609-17.(SCI).
  14. Shi YC, Liao JW, Pan TM. Anti-hypertriglyceridemia and anti-inflammatory activities of Monascus-fermented dioscorea in streptozotocin-induced diabetic rats. Exp Diabetes Res. 2011; 2011: Article ID 710635, 11 pages, doi:10.1155/2011/.(SCI).
  15. Lee BH, Liao JW, Wang CT, Pan TM. The traditional Chinese medicine, Monascus-fermented rice, preventing Zn deficiency-induced testes and sperm injury. J Food Drug Analysis. 2011; 19(2): 183-90.(SCI).
  16. Hsu WH, Lee BH, Pan TM. Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model. Food Chem Toxicol. 2011; 49(6): 1292-7.(SCI).
  17. Lee BH, Hsu WH, Pan TM. Inhibitory effects of dioscorea polysaccharide on TNF-α induced insulin resistance in the mouse FL83B cells. J Agric Food Chem. 2011; 59(10): 5279-85.(SCI).
  18. Liu CF, Tung YT, Wu CL, Lee BH, Hsu WH, Pan TM. Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats. J Agric Food Chem. 2011; 59(9): 4537-43.(SCI).
  19. Hsu YW, Hsu LC, Liang YH, Kuo YH, Pan TM. New bioactive orange pigments with yellow fluorescence from Monascus-fermented dioscorea. J Agric Food Chem. 2011; 59(9): 4512-8.(SCI).
  20. Liu CF, Tseng KC, Chiang SS, Lee BH, Hsu WH, Pan TM. Immunomodulatory and antioxidant potential of Lactobacillus exopolysaccharides. J Sci Food Agric. 2011; 91(12): 2284-91.(SCI).
  21. Shi YC, Pan TM. Beneficial effects of Monascus purpureus NTU 568-fermented products: a review. Appl Microbiol Biotechnol. 2011; 90(4): 1207-17.(SCI).
  22. Chiang SS, Liu CF, Ku TW, Mau JL, Lin HT, Pan TM. Use of murine models to detect the allergenicity of genetically modified Lactococcus lactis NZ9000/pNZPNK. J Agric Food Chem. 2011; 59(8): 3876-83.(SCI).
  23. Lin CH, Pan TM. Assessing the digestion of a genetically modified tomato (Solanum lycopersicum) R8 DNA in simulated gastric fluid using event-specific real-time PCR. Eur Food Res Technol. 2011; 232(6): 1061-7.(SCI).
  24. Chuang CY, Shi YC, You HP, Lo YH, Pan TM. Antidepressant effect of GABA-rich Monascus-fermented product on forced swimming rat model. J Agric Food Chem. 2011; 59(7): 3027-34.(SCI).
  25. Chang YY, Lee BH, Huang T, Pan TM. Improvement effects of monacolin K from Monascus-fermented products on insulin resistance of mouse liver cell lines. Taiwanese J Agric Chem & Food Sci. 2011; 49(2): 82-8
  26. Hsu LC, Hsu YW, Liang YH, Kuo YH, Pan TM. Anti-tumor and anti-inflammatory properties of ankaflavin and monaphilone A from monascus purpureus NTU 568. J Agric Food Chem. 2011; 59(4): 1124-30.(SCI).
  27. Wu CL, Kuo YH, Lee CL, Hsu YW, Pan TM. Synchronous high-performance liquid chromatography with a photodiode array detector and mass spectrometry for the determination of citrinin, monascin, ankaflavin, and the lactone and acid forms of monacolin K in red mold rice. J AOAC Int. 2011; 94(1): 179-90.(SCI). 
2010
  1. Shi YC, Pan TM. Characterization of a multifunctional Monascus isolate NTU 568 with high azaphilone pigments production. Food Biotec. 2010; 24(4): 349-63. (SCI)
  2. Jou PC, Ho BY, Hsu YW, Pan TM. The effect of Monascus secondary polyketide metabolites, monascin and ankaflavin, on adipogenesis and lipolysis activity in 3T3-L1. J Agric Food Chem. 2010; 58(24): 12703-9. (SCI)
  3. Hsu WH, Lee BH, Pan TM. Red mold dioscorea-induced G2/M arrest and apoptosis in human oral cancer cells. J Sci Food Agric. 2010; 90(15): 2709-15. (SCI)
  4. Wu MH, Pan TM, Wu YJ, Chang SJ, Chang MS, Hu CY. Exopolysaccharide activities from probiotic bifidobacterium: Immunomodulatory effects (on J774A.1 macrophages) and antimicrobial properties. Int J Food Microbiol. 2010; 144(1): 104-10. (SCI)
  5. Shi YC, Pan TM. Antioxidant and pancreas-protective effect of red mold fermented products on streptozotocin-induced diabetic rats. J Sci Food Agric. 2010; 90(14): 2519-25. (SCI)
  6. Hsu YW, Hsu LC, Chang CL, Liang YH, Kuo YH, Pan TM. New anti-inflammatory and anti-proliferative constituents from fermented red mold rice Monascus purpureus NTU 568. Molecules. 2010; 15(11): 7815-24. (SCI)
  7. Tsai YT, Cheng PC, Pan TM. Immunomodulating activity of Lactobacillus paracasei subsp. paracasei NTU 101 in enterohemorrhagic Escherichia coli O157:H7-infected mice. J Agric Food Chem. 2010; 58(21): 11265–72. (SCI)
  8. Liu CF, Pan TM. Recombinant expression of bioactive peptide lunasin in Escherichia coliAppl Microbiol Biotechnol. 2010; 88(1): 177-86. (SCI)
  9. Lee KC, Liu CF, Lin TH, Pan TM. Safety and risk assessment of the genetically modified Lactococci on rats intestinal bacterial flora. Int J Food Microbiol. 2010; 142(1-2): 164-9. (SCI)
  10. Lee CL, Kung YH, Wu CL, Hsu YW, Pan TM. Monascin and ankaflavin act novel hypolipidemic and high density lipoprotein cholesterol-raising agents in red mold dioscorea. J Agric Food Chem. 2010; 58(16): 9013-9. (SCI)
  11. Hsu YW, Hsu LC, Liang YH, Kuo YH, Pan TM. Monaphilones A-C, three new antiproliferative azaphilone derivatives from Monascus purpureus NTU 568. J Agric Food Chem. 2010; 58(14): 8211-6. (SCI)
  12. Shi YC, Pan TM. Anti-diabetic effects of Monascus purpureus NTU 568 fermented products on streptozotocin-induced diabetic rats. J Agric Food Chem. 2010; 58(13): 7634-40. (SCI)
  13. Tsai YT, Cheng PC, Liao JW, Pan TM. Effect of the administration of Lactobacillus paracasei subsp. paracasei NTU 101 on Peyer's patch-mediated mucosal immunity. Int Immunopharmacol. 2010; 10(7): 791-8. (SCI)
  14. Lee CL, Kung YH, Tsai WL, Chung MY, Pan TM. Studies on body fat-lowering effects of a commercial Monascus-fermented product using a high-fat diet-induced obese rat model. Taiwanese J Agric Chem & Food Sci. (in Chinese) 2010; 48(3): 128-37.
  15. Ho BY, Wu YM, Hsu YW, Hsu LC, Kuo YH, Chang KJ, Pan TM. Effects of Monascus-fermented rice extract on malignant cell-associated neovascularization and intravasation determined using the chicken embryo chorioallantoic membrane model. Integr Cancer Ther. 2010; 9(2): 204-12. (SCI)
  16. Lee CH, Lee CL, Pan TM. A 90-d toxicity study of Monascus-fermented products including high citrinin level. J Food Sci. 2010; 75(5): T91-7. (SCI)
  17. Hsu WH, Lee BH, Pan TM. Protection of Monascus-fermented dioscorea against DMBA-induced oral injury in hamster by anti-inflammatory and antioxidative potentials. J Agric Food Chem. 2010; 58(11): 6715-20. (SCI)
  18. Lin CH, Pan TM. PCR-denaturing gradient gel electrophoresis analysis to assess the effects of a genetically modified cucumber mosaic virus-resistant tomato plant on soil microbial communities. Appl Environ Microbiol. 2010; 76(10): 3370-3. (SCI)
  19. Liu CF, Pan TM. In vitro effects of lactic acid bacteria on cancer cell viability and antioxidant activity. J Food Drug Analysis. 2010; 18(2): 77-86. (SCI)
  20. Liao DH, Lee BH, Pan TM. Antioxidative properties of the extracts from wheaten embryo. Taiwanese J Agric Chem & Food Sci. (in Chinese) 2010; 48(2): 92-8.
  21. Chen SW, Shi YC, Lee BH, Pan TM. Effect of Monascus fermented rice on the sperm morphology and reproductive performance in zinc deficient rats. Taiwanese J Agric Chem & Food Sci. (in Chinese) 2010; 48(2): 74-83.
  22. Lu IJ, Lin CH, Pan TM. Establishment of a system based on universal multiplex-PCR for screening genetically modified crops. Anal Bioanal Chem. 2010; 396(6): 2055-64. (SCI)
  23. Lee CL, Kuo TF, Wu CL, Wang JJ, Pan TM. Red mold rice promotes neuroprotective sAPPalpha secretion instead of Alzheimer's risk factors and amyloid beta expression in hyperlipidemic Aβ40-infused rats. J Agric Food Chem. 2010; 58(4): 2230-8. (SCI)
  24. Lin CH, Sheu F, Lin HT, Pan TM. Allergenicity assessment of genetically modified cucumber mosaic virus (CMV) resistant tomato (Solanum lycopersicon). J Agric Food Chem. 2010; 58(4): 2302-6. (SCI)
 2009
  1. Ku TW, Tsai RL, Pan TM. A simple and cost-saving approach to optimize the production of subtilisin NAT by submerged cultivation of Bacillus subtilis natto. J Agric Food Chem. 2009; 57(1): 292-6. (SCI)
  2. Lin CH, Lu CT, Lin HT, Pan TM. Safety assessment and detection method of genetically modified Chinese kale (Brassica oleracea cv. alboglabra). J Agric Food Chem. 2009; 57(5): 1876-81. (SCI)
  3. Tsai TY, Chu LH, Lee CL, Pan TM. Atherosclerosis-preventing activity of lactic acid bacteria-fermented milk-soymilk supplemented with Momordica charantiaJ Agric Food Chem. 2009; 57(5): 2065-71. (SCI)
  4. Liu CF, Hu CL, Chiang SS, Tseng KC, Yu RC, Pan TM. Beneficial preventive effects of gastric mucosal lesion for soy-skim milk fermented by lactic acid bacteria. J Agric Food Chem. 2009; 57(10): 4433-8. (SCI)
  5. Wu CL, Lee CL, Pan TM. Red mold dioscorea has a greater antihypertensive effect than traditional red mold rice in spontaneously hypertensive rats. J Agric Food Chem. 2009; 57(11): 5035-41. (SCI)
  6. Ho BY, Pan TM. The Monascus metabolite monacolin K reduces tumor progression and metastasis of Lewis lung carcinoma cells. J Agric Food Chem. 2009; 57(18): 8258-65. (SCI)
  7. Lee BH, Ho BY, Wang CT, Pan TM. Red mold rice promoted antioxidase activity against oxidative injury and improved the memory ability of zinc-deficient rats. J Agric Food Chem. 2009; 57(22): 10600-7. (SCI)
  8. Wang TL, Pan TM, Kung ZL. Study on hypolipidemic effect of complex liquior containing red mold rice. Taiwan Journal of Dietetics. (in Chinese) 2009; 1(2): 13-20.
 2008
  1. Tsai YT, Cheng PC, Fan CK, Pan TM. Time-dependent persistence of enhanced immune response by a potential probiotic strain Lactobacillus paracasei subsp. paracasei NTU 101. Int J Food Microbiol. 2008; 128(2): 219-25. (SCI)
  2. Yu CC, Wang JJ, Lee CL, Lee SH, Pan TM. Safety and mutagenicity evaluation of nanoparticulate red mold rice. J Agric Food Chem. 2008; 56(22): 11038-48. (SCI)
  3. Wang CT, Huang KC, Pan TM, Chang KJ, Chang WT, Chou SS. Variations in the concentrations of Cu and Zn and in the ratio of Cu to Zn in whole blood and hair samples from hepatocellular carcinoma patients and from healthy controls in Taiwan. Spectrosc Lett. 2008; 41(3): 144-50. (SCI)
  4. Pan TM. The application and the status of intellectual property rights (IPR) protection of red mold rice. J Life Sci. 2008; 2(4): 38-53.
  5. Lee CL, Wang JJ, Pan TM. Red mold rice extract represses amyloid beta peptide-induced neurotoxicity via potent synergism of anti-inflammatory and antioxidative effect. Appl Microbiol Biotechnol. 2008; 79(5): 829-41. (SCI)
  6. Hsieh JM, Chen RS, Tsai TY, Pan TM, Chou CC. Phylogenetic analysis of livestock oxacillin-resistant Staphylococcus aureusVet Microbiol. 2008; 126(1-3): 234-42. (SCI)
  7. Chen WP, Ho BY, Lee CL, Lee CH, Pan TM. Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet. Int J Obes. 2008; 32(11): 1694-704. (SCI)
  8. Lin WY, Chang JY, Hish CH, Pan TM. Profiling the Monascus pilosus proteome during nitrogen limitation. J Agric Food Chem. 2008; 56(2): 433-41. (SCI)
 2007
  1. Lin WY, Chang JY, Hish CH, Pan TM. Proteome response of Monascus pilosus during rice starch limitation with suppression of monascorubramine production. J Agric Food Chem. 2007; 55(22): 9226-34. (SCI)
  2. Yang IC, Shih DY, Wang JY, Pan TM. Development of rapid real-time PCR and most-probable-number real-time PCR assays to quantify enterotoxigenic strains of the species in the Bacillus cereus group. J Food Prot. 2007; 70(12): 2774-81. (SCI)
  3. Lee CL, Chen WP, Wang JJ, Pan TM. A simple and rapid approach for removing citrinin while retaining monacolin K in red mold rice. J Agric Food Chem. 2007; 55(26): 11101-8. (SCI)
  4. Lee CL, Kuo TF, Wang JJ, Pan TM. Red mold rice ameliorates impairment of memory and learning ability in intracerebroventricular amyloid beta-infused rat by repressing amyloid beta accumulation. J Neurosci Res. 2007; 85(14): 3171-82. (SCI)
  5. Pan TM. Regulation and current status of health food in Taiwan. Bioindustry. 2007; 18(1): 1-3.
  6. Huang YJ, Tsai TY, Pan TM. Physiological response and protein expression under acid stress of Escherichia coli O157:H7 TWC01 isolated from Taiwan. J Agric Food Chem. 2007; 55(17): 7182-91. (SCI)
  7. Pan TM. Global genetically modified crop production and the regulation of genetically modified food in Taiwan. Agricultural Biotechnology Industry Quarterly. 2007; 9: 25-37.
  8. Pan TM. Current status of the application and intelligence property of red mold rice. Bioindustry. 2007; 18(1): 18-43.
  9. Chiu CH, Guu YK, Liu CH, Pan TM, Cheng W. Immune responses and gene expression in white shrimp, Litopenaeus vannamei, induced by Lactobacillus plantarumFish Shellfish Immunol. 2007; 23(2): 364-77. (SCI)
  10. Lin WY, Hsu WY, Hish CH, Pan TM. Proteome changes in Caco-2 cells treated with Monascus-fermented red mold rice extract. J Agric Food Chem. 2007; 55(22): 8987-94. (SCI)
  11. Lee CL, Hung HK, Wang JJ, Pan TM. Red mold dioscorea has greater hypolipidemic and antiatherosclerotic effect than traditional red mold rice and unfermented dioscorea in hamsters. J Agric Food Chem. 2007; 55(17): 7162-9. (SCI)
  12. Lee CL, Hung HK, Wang JJ, Pan TM. Improving the ratio of monacolin K to citrinin production of Monascus purpureus NTU 568 under dioscorea medium through the mediation of pH value and ethanol addition. J Agric Food Chem. 2007; 55(16): 6493-502. (SCI)
  13. Lin WY, Chang JY, Tsai PC, Pan TM. Metabolic protein patterns and monascorubrin production revealed through proteomic approach for Monascus pilosus treated with cycloheximide. J Agric Food Chem. 2007; 55(14): 5559-68. (SCI)
  14. Lin WY, Ting YC, Pan TM. Proteomic response to intracellular proteins of Monascus pilosus grown under phosphate-limited complex medium with different growth rates and pigment production. J Agric Food Chem. 2007; 55(2): 467-74. (SCI)
 2006
  1. Tsai TY, Lee WJ, Huang YJ, Chen KL, Pan TM. Detection of viable enterohemorrhagic Escherichia coli O157 using the combination of immunomagnetic separation with the reverse transcription multiplex TaqMan PCR system in food and stool samples. J Food Prot. 2006; 69(10): 2320-8. (SCI)
  2. Chang CY, Lee CL, Pan TM. Statistical optimization of medium components for the production of Antrodia cinnamomea AC0623 in submerged cultures. Appl Microbiol Biotechnol. 2006; 72(4): 654-61. (SCI)
  3. Lee CL, Wang JJ, Kuo SL, Pan TM. Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent--monacolin K and antiinflammation agent--monascin. Appl Microbiol Biotechnol. 2006; 72(6): 1254-62. (SCI)
  4. Chiu CH, Ni KH, Guu YK, Pan TM. Production of red mold rice using a modified Nagata type koji maker. Appl Microbiol Biotechnol. 2006; 73(2): 297-304. (SCI)
  5. Yu CC, Lee CL, Pan TM. A novel formulation approach for preparation of nanoparticulate red mold rice. J Agric Food Chem. 2006; 54(18): 6845-51. (SCI)
  6. Lin WY, Song CY, Pan TM. Proteomic analysis of Caco-2 cells treated with monacolin K. J Agric Food Chem. 2006; 54(17): 6192-200. (SCI)
  7. Chang CY, Lue MY, Pan TM. Isolation and identification of two Antrodia cinnamomea strains from fruiting bodies. J Food Drug Analysis. 2006; 14(2): 174-82. (SCI)
  8. Lee CL, Wang JJ, Pan TM. Synchronous analysis method for detection of citrinin and the lactone and acid forms of monacolin K in red mold rice. J AOAC Int. 2006; 89(3): 669-77. (SCI)
  9. Wang JJ, Shieh MJ, Kuo SL, Lee CL, Pan TM. Effect of red mold rice on antifatigue and exercise-related changes in lipid peroxidation in endurance exercise. Appl Microbiol Biotechnol. 2006; 70(2): 247-53. (SCI)
  10. Tsai TY, Luo WC, Chen KL, Pan TM. Molecular subtyping of Salmonella enterica serovar enteritidis isolated from Taiwan during 1992-1998 by amplified fragment length polymorphism and pulsed-field gel electrophoresis. J Food Drug Analysis. 2006; 14(1/2): 54-61. (SCI)
  11. Hsieh YT, Pan TM. Influence of planting papaya ringspot virus resistant transgenic papaya on soil microbial biodiversity. J Agric Food Chem. 2006; 54(1): 130-7. (SCI)
  12. Chiu CH, Lu TY, Tseng YY, Pan TM. The effects of Lactobacillus-fermented milk on lipid metabolism in hamsters fed on high-cholesterol diet. Appl Microbiol Biotechnol. 2006; 71(2): 238-45. (SCI)
  13. Lee CL, Tsai TY, Wang JJ, Pan TM. In vivo hypolipidemic effects and safety of low dosage Monascus powder in a hamster model of hyperlipidemia. Appl Microbiol Biotechnol. 2006; 70(5): 533-40. (SCI)
  14. Wang JJ, Pan TM, Shieh MJ, Hsu CC. Effect of red mold rice supplements on serum and meat cholesterol levels of broilers chicken. Appl Microbiol Biotechnol. 2006; 71(6): 812-8. (SCI)
 2005
  1. Chang CY, Lue MY, Pan TM. Determination of adenosine, cordycepin and ergosterol contents in cultivated Antrodia camphorata by HPLC method. J Food Drug Analysis. 2005; 13(4): 338-42. (SCI)
  2. Lee CL, Tsai TY, Gong SD, Shih CJ, Chung MY, Pan TM. Study on hypolipidemic effects of Monascus powder in a hamster model of hyperlipidemia. Taiwanese J Agric Chem & Food Sci. 2005; 43(4): 271-80.
  3. Su HP, Tseng LR, Chou CY, Chung TC, Pan TM. Legionella pneumophila infection in the Taiwan area. J Infect Chemother. 2005; 11(5): 244-9. (SCI)
  4. Su HP, Chiu SI, Tsai JL, Lee CL, Pan TM. Bacterial food-borne illness outbreaks in northern Taiwan, 1995-2001. J Infect Chemother. 2005; 11(3): 146-51. (SCI)
  5. Wu FT, Tsai TY, Hsu CF, Pan TM, Chen HY, Su IJ. Isolation and identification of Escherichia coli O157:H7 in a Taiwanese patient with bloody diarrhea and acute renal failure. J Formos Med Assoc. 2005; 104(3): 206-9. (SCI)
  6. Hsu CF, Tsai TY, Pan TM. Use of the duplex TaqMan PCR system for detection of Shiga-like toxin-producing Escherichia coli O157. J Clin Microbiol. 2005; 43(6): 2668-73. (SCI)
  7. Huang CC, Pan TM. Event-specific real-time detection and quantification of genetically modified Roundup Ready soybean. J Agric Food Chem. 2005; 53(10): 3833-9. (SCI)
  8. Tsai TY, Luo WC, Wu FT, Pan TM. Molecular subtyping for Escherichia coli O157: H7 isolated in Taiwan. Microbiol Immunol. 2005; 49(7): 579-88. (SCI)
  9. Yang IC, Shih DY, Huang TP, Huang YP, Wang JY, Pan TM. Establishment of a novel multiplex PCR assay and detection of toxigenic strains of the species in the Bacillus cereus group. J Food Prot. 2005; 68(10): 2123-30. (SCI)
 2004
  1. Chu LH, Tsai TY, Pan TM. Study on the water extract of anamorph of Cordyceps sinensis fermented by Lactobacillus paracasei subsp. paracasei NTU101 isolated from Taiwan. J Biomass Energy Soc China. 2004; 23(3/4): 117-25.
  2. Pan TM. Development of functional food with the effect of lowing cholesterol. Bioindustry. 2004; 15(4): 3-24.
  3. Pan TM. Fermentative functional food-peptides. Bioindustry. 2004; 15(4): 79-91.
  4. Lin FM, Chiu CH, Pan TM. Fermentation of a milk-soymilk and Lycium chinense Miller mixture using a new isolate of Lactobacillus paracasei subsp. paracasei NTU101 and Bifidobacterium longumJ Ind Microbiol Biotechnol. 2004; 31(12): 559-64. (SCI)
  5. Wang JJ, Lee CL, Pan TM. Modified mutation method for screening low citrinin-producing strains of Monascus purpureus on rice culture. J Agric Food Chem. 2004; 52(23): 6977-82. (SCI)
  6. Huang CC, Shih TW, Pan TM. Development and application of a nested polymerase chain reaction method for the detection of genetically modified soybean in Chinese traditional fermented soy food-sufu. J Food Drug Analysis. 2004; 12(3): 266-72. (SCI)
  7. Pan TM. Safety issue of genetically modified food. Bioindustry. 2004; 15(2): 57-62.
  8. Pan TM. Free radicals and disease. Bioindustry. 2004; 15(2): 47-56.
  9. Pan TM. Functional food-Red mold rice. NTU Biomed Bulletin. 2004; 25: 2-20.
  10. Pan TM, Chan WL. Study on the detection of genetically modified maize GA21, NK603 and MON810 by a multiplex PCR method. J Biomass Energy Soc China. 2004; 23(1/2): 37-49.
  11. Pan TM. Functional lactic-acid bacterial product. NTU Biomed Bulletin. 2004; 23(2-13).
  12. Pan TM. Development of global genetically modified organism in 2003. Bioindustry. 2004; 15(1): 37-50.
  13. Huang HY, Pan TM. Detection of genetically modified maize MON810 and NK603 by multiplex and real-time polymerase chain reaction methods. J Agric Food Chem. 2004; 52(11): 3264-8. (SCI)
 2003
  1. Pan TM. Management and distribution of functional food in Taiwan. NTU Biomed Bulletin. 2003; 21: 27-34.
  2. Pan TM. Production of alditol. Bioindustry. 2003; 14(4): 54-62.
  3. Pan TM. Lactic acid bacteria and hypertension. Bioindustry. 2003; 14(4): 76-83.
  4. Wang JJ, Lee CL, Pan TM. Improvement of monacolin K, γ-aminobutyric acid and citrinin production ratio as a function of environmental conditions of Monascus purpureus NTU 601. J Ind Microbiol Biotechnol. 2003; 30(11): 669-76. (SCI)
  5. Pan T-M. Biotoxin. Bioindustry. 2003; 14(3): 39-44.
  6. Cheng HW, Pan TM. Studies on the effect of olive oil on lipid metabolism. J Biomass Energy Soc China. 2003; 22(3/4): 103-13.
  7. Pan TM. New application of red mold rice. Bioresource Biotechnology. 2003; 5(2): 3.
  8. Pan TM. Fermantative functional food-oligosaccharide and polysaccharide. Bioindustry. 2003; 14(2): 59-73.
  9. Wang JJ, Pan TM. Effect of red mold rice supplements on serum and egg yolk cholesterol levels of laying hens. J Agric Food Chem. 2003; 51(16): 4824-9. (SCI)
  10. Su YC, Wang JJ, Lin TT, Pan TM. Production of the secondary metabolites γ-aminobutyric acid and monacolin K by MonascusJ Ind Microbiol Biotechnol. 2003; 30(1): 41-6. (SCI)
  11. Pan TM. Development of global genetically modified organism in 2002. Bioindustry. 2003; 14(1): 44-52.
  12. Pan TM, Tseng TW. Detecting two events of genetically modified maize by a multiplex PCR method. Food Sci Agric Chem. 2003; 5(2): 59-65.
  13. Pan TM, Shih TW. Detection of genetically modified soybeans in Chou-Tou-Fu and Tou-Fu-Ju by polymerase chain reaction. Taiwanese J Agric Chem & Food Sci. 2003; 41(4): 263-7.
  14. Pan TM, Shih TW. Detection of genetically modified soybeans in miso by polymerase chain reaction and nested polymerase chain reaction. J Food Drug Analysis. 2003; 11(2): 154-8. (SCI)
 2002
  1. Luo WC, Pan TM. Investigation of the antibiotic resistance of Enterobacteriaceae of swines in Taiwan. Taiwanese J Agric Chem & Food Sci. 2002; 40(2): 76-85.
  2. Lin KC, Wang JJ, Pan TM. Screening of di-(2-ethylhexyl) phthalate-degrading microorganism and optimization of biodegradation conditions. Taiwanese J Agric Chem & Food Sci. 2002; 40(3): 144-51.
  3. Pan TM, Chen LM, Su YC. Identification of Escherichia coli O157:H7 by multiplex PCR with primers specific to the hlyA, eaeA, stx1, stx2, fliC and rfb genes. J Formos Med Assoc. 2002; 101(9): 661-4. (SCI)
  4. Wang CT, Chang WT, Pan TM, Wang RT. Blood concentrations of Selenium, Zinc, Iron, Copper and Calcium in patients with hepatocellular carcinoma. Clin Chem Lab Med. 2002; 40(11): 1118-22. (SCI)
  5. Pan TM, Chiu CH, Gun YK. Characterization of Lactobacillus isolates from pickled vegetables for use as dietary or pickle adjuncts. Foods Food Ingredients J Jpn. 2002; 206: 45-51.
  6. Pan TM, Lee JL. Red mold rice and functional food. Bioindustry. 2002; 13: 488-94.
  7. Pan TM, Lun JY. Lactic acid bacteria and functional food. Bioindustry. 2002; 13: 495-9.
  8. Hsieh YT, Pan TM. The analytical methods and assays for secondary metabolites of Monascus products. J Biomass Energy Soc China. 2002; 21(1/2): 63-71.
  9. Pan TM, Liu YJ. Identification of Salmonella enteritidis isolates by polymerase chain reaction and multiplex polymerase chain reaction. J Microbiol Immunol Infect. 2002; 35(3): 147-51. (SCI)
  10. Pan TM. Current status and detection of genetically modified organism. J Food Drug Analysis. 2002; 10(4): 229-41. (SCI)
  11. Pan TM. Benefit and impact of genetically modified organism. Bioindustry. 2002; 13: 441-51.
  12. Pan TM. Introduction to the evaluation of functional food. Bioindustry. 2002; 13: 464-73.
  13. Pan TM. Bioinformatics and bioindustry. Bioindustry. 2002; 13: 528-35.
 2001
  1. Lin CS, Wang TK, Lee CL, Pan TM, Tsai JL, Ho SI, Lu CH. Molecular epidemiology of newly emerged V. cholerae O139 in Taiwan. J Food Drug Analysis. 2001; 9(4): 224-31. (SCI)
  2. Pan TM, Liu YJ. Pulsed-field gel electrophoresis, specific detection using PCR, and antibiotic resistance patterns of Salmonella enteritidis isolated in Taiwan, 1992-1998. J Biomass Energy Soc China. 2001; 20(3/4): 69-78.
  3. Lin CS, Wang TK, Tsai JL, Ho SI, Lee CL, Chen HY, Pan TM. Relationship analysis of the oubbreak of shigellosis at Tau-Yuan area. Epidemiol Bull. 2001; 17(4): 168 -80.
  4. Lin YL, Chou CC, Pan TM. Screening procedure from cattle feces and the prevalence of Escherichia coli O157:H7 in Taiwan dairy cattle. J Microbiol Immunol Infect. 2001; 34(1): 17-24. (SCI)
 2000
  1. Pan TM, Liu ER. Examination of genetically modified foods. Bioindustry. 2000; 11: 218-24.
  2. Cheng AL, Pan TM, Hung HP, Huang CJ. Intestinal microflora is improved by the feeding of an oligosaccharide containing soft drink in rats. Nutr Sci J. 2000; 25(4): 232-42.
  3. Lee TM, Chang LL, Chang CY, Wang JC, Pan TM, Wang TK, Chang SF. Molecular analysis of Shigella sonnei isolated from three well-documented outbreaks in school children. J Med Microbiol. 2000; 49(4): 355-60. (SCI)
 1999
  1. Chen MK, Wang CC, Chu ML, Pan TM. Prospective surveillance of children with invasive Haemophilus influenzae disease in Taiwan. J Microbiol Immunol Infect. 1999; 32(4): 257-60. (SCI)
  2. Lin CS, Wang TK, Tsai JL, Ho SI, Lee CL, Chen HY, Pan TM. Relatedness of Shigella sonnei isolates from six outbreaks in Tao-Yuan area, Taiwan. J Microbiol Immunol Infect. 1999; 32(4): 278-82. (SCI)
  3. Lu KL, Jiang DD, Chen KT, Pan TM, Tu ST, Chen CJ. Molecular epidemiological study of a shigellosis outbreak in Kuanhsi township, Hsinchu county. Epidemiol Bull. 1999; 15(11): 375-84.
  4. Wong HC, Liu CC, Pan TM, Wang TK, Lee CL, Shih DY. Molecular typing of Vibrio parahaemolyticus isolates, obtained from patients involved in food poisoning outbreaks in Taiwan, by random amplified polymorphic DNA analysis. J Clin Microbiol. 1999; 37(6): 1809-12. (SCI)
  5. Wu FT, Pan TM. Rapid detection of pathogenic Escherichia coli by polymerase chain reaction. J Chin Agric Chem Soc. 1999; 37(2): 179-89.
  6. Wang TK, Tsai JL, Lin CS, Ho SI, Chiou CS, Hsu SY, Huang HC, Pan TM. Recent trend of Salmonella food poisoning and serovars. Epidemiol Bull. 1999; 15(1): 1-7.
  1. Pan TM. Risk Management Systems in Biotechnlogy SMEs. In: Teng PPS, ed. Report of the APO Asian Food and Agribusiness Conference 2013:​ Biotechnology and Global Competitiveness, 15–18 July 2013, Republic of China. Tokyo, Japan: Asian Productivity Organization; 2015: 117-30.
  2. Pan TM, Hsu WH. Monascus-Fermented Products. In: Batt CA, Tortorello ML, eds. Encyclopedia of Food Microbiology, ISBN: 978-0-12-384730-0. 2 ed: Elsevier Ltd, Academic Press,; 2014. p. 815-25.
  3. Hsu WH, Pan TM. A novel adjuvant therapeutic material : chemoprevention of Monascus-fermented product on oral cancer. In: Harris MK, editor. Oral Cancer: causes, diagnosis, and treatment, ISBN: 978-1-61209-305-5. Hauppauge, N.Y.: Nova Science Publishers; 2011. p. 233-52.
  4. Lin CH, Pan TM. Safety assessment of genetically modified (GM) crops: current protocol, research trend and future challenge. In: Grover LM, editor. Genetically engineered crops : biotechnology, biosafety, and benefits,  ISBN: 978-1-61122-526-6. Hauppauge, N.Y.: Nova Science; 2011. p. 131-52.
  5. Liu CF, Pan TM. Beneficial effects of bioactive peptides derived from soybean on human health and their production by genetic engineering. In: El-Shemy H, editor. Soybean and health, ISBN 978-953-307-535-8: InTech; 2011. p. 311-28.
  6. 潘子明. 發現紅麴新價值: 健康文化事業股份有限公司; 2009.潘子明. 基因改造食品: 九州圖書文物有限公司; 2004.
  1. Pan TM, Lee CL, A method for manufacturing a red mold dioscorea. Korea patent 10-1227332. 2013.
  2. Lee CL, Pan TM. Composition and Method for Prevention and Treatment of Alzheimer's Disease. Canada patent 2616971. 2012.
  3. 潘子明, 李俊霖. 紅麴山藥之製作方法. 日本專利特許第 4948609. 2012 (2012.04.20-2027.04.20).
  4. 潘子明, 李俊霖. 紅麴應用於改善阿茲海默鼠學習記憶能力. 日本專利特許第 4974031. 2012 (2012.03.16-2027.03.16).
  5. 潘子明, 李俊霖. 紅麴山藥之製作方法. 中華民國 發明 專利 I350733. 2011. (2011/10/21~2029/04/23).
  6. 潘子明, 李俊霖. 紅麴應用於改善阿茲海默鼠學習記憶能力. 新加坡 專利 0719013-5. 2011. (2011/8/11-2025/8/10).
  7. 潘子明, 李俊霖. 紅麴應用於改善阿茲海默鼠學習記憶能力. 韓國 專利 10-0959001. 2011. (2011/5/12-2025/5/11).
  8. 潘子明, 李俊霖. 治療與預防阿茲海默症之組合物及其製作方法. 中華民國 發明 專利 I341204. 2011. (2011/05/01~2027/12/27).
  9. 楊怡真, 黃翠萍, 黃蘊璞, 潘子明, 王貞懿, 施養志, 孫慈悌. 快速及高專一性檢測仙人掌桿菌腹瀉型腸毒素基因之多重組對引子. 中華民國 發明 專利 I290557. 2007. (2007/12/01~2024/12/02).
  10. Pan TM, Wang CC. Method for producing eggs with low cholesterol level. United States Utility patent 7,157,107. 2007. (2007/01/02~2015/01/02).