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Core faculty

Distinguished Professor Ja-An Annie Ho

Ja-An Annie Ho Professor

Ja-An Annie Ho

Title Distinguished Professor
Education Ph.D., Cornell University
Research Expertise Biosensor development, Targeted drug delivery system development, Bioanalytical chemistry
LAB BioAnalytical Chemistry and Nanobiomedicine Lab. (AC2-307)
TEL +886-2-3366-4438
Personal webpage


Highlight I Liposomes in Flow Injection Systems

1. Application of Liposomal Bioluminescent Label in the Development of Flow Injection ImmunoAnalytical System [Anal. Chem200577 (11), 3431–3436]; illustrated in Figure 2
2. Application of Ganglioside‐Sensitized Liposomes in a Flow Injection Immunoanalytical System for the Determination of Cholera Toxin [Anal. Chem200779 (1), 246–250].



Highlight II Development of Electrochemial Immunosensors

1. Electrochemical Immunosensor for Cholera Toxin Using Liposomes and poly(3,4‐ ethylenedioxythiophene)‐Coated Carbon Nanotubes [Anal. Chem200678 (4), 1115–1121]; illustrated in Figure 3.
2. Dual Electrochemical Determination of Glucose and Insulin Using Enzyme and Ferrocene Microcapsules [Biosens. Bioelectron200722, 1147–1153]; illustrated in Figure 4.


Highlight III Liposomes in Immunoaffinity Chromatographic Biosensors

1. Using Liposomal Fluorescent Biolabels To Develop an Immunoaffinity Chromatographic Biosensing System for Biotin [Anal. Chem200880 (16), 6405–6409]; illustrated in Figure 5.



  1. Chen, C.C., Fa, Y.C., Kuo, Y.Y., Liu, Y.C., Lin, C.Y., Wang, X.H. Wang, Lu, Y.H., Chiang, Y.H., Yang, C.M.*, Wu, L.C.*, Ho, J.-a. A.* (2022). Thiolated Mesoporous Silica Nanoparticles as an Immunoadjuvant to Enhance Efficacy of Intravesical Chemotherapy for Bladder Cancer. Advanced Science, doi: 0.1002/advs.202204643. (SCI)
  2. Herianto, S., Chien, P.J., Ho, J.-a. A., Tu, H.L.* (2022). Liposome-based artificial cells: From gene expression to reconstitution of cellular functions and phenotypes. Biomaterials Advances, 142, 213156, doi: 10.1016/j.bioadv.2022.213156.
  3. Chou, S.W., Chen, T.H., Fa, Y.C., Yang, Y.Y., Lin, C.Y., Kuo, K.L., Wu, S.T., Lin, E.C.*, Ho, J.-a. A.*, Hsiao, J.K.*, Chou, P.T.* (2022). Gadolinium-Engineered Magnetic Alloy Nanoparticles for Magnetic Resonance T 1 /T 2 Dual-Modal and Computed Tomography Imaging. Chemistry of Materials, 34(22), 10050-10058. (SCI)
  4. Lee, Y.L., Chou, Y.T., Su, B.K., Wu, C.C., Wang, C.H., Chang, K.H., Ho, J.-a. A.*, Chou, P.T.* (2022). Comprehensive Thione-Derived Perylene Diimides and Their Bio-Conjugation for Simultaneous Imaging, Tracking, and Targeted Photodynamic Therapy. Journal of the American Chemical Society, 144(37), 17249- 17260. (SCI)
  5. Tsai, C.-Y., Huang, D.-Y., Ho, J.-a. A.*, Wu, L.-C* (2022). Evaluation of the apolipoprotein E (apoE)-HDL- associated risk factors for coronary heart disease using duo-functional electrochemical aptasensor. Analytical and Bioanalytical Chemistry, 141(18), 5595-5607. (SCI)
  6. Wu, P.C., Guo, L.Z., Yu, S., Zeng, N., Liu, Y.C., Yu, J., Zhang, Z., Lu, K., Sun, L., Wang, C., Chang, Y.H., Lu, Y.L., Shen, Y.F., Tai, S., Chuang, Y.H., Ho, J.-a. A., Huang, K.W., Wu, Y.M. and Liu, T.M.* (2022). Noninvasive assessment of liver function reserve with fluorescent dosimetry of indocyanine green. Biomedical Optics Express, 13(4), 1995-2005. (SCI)
  7. Lin, P.-Y., Chi, R., Wu, Y.-L., Ho, J.-a. A.* (2022). Applications of triplex DNA nanostructures in sensor development. Analytical and Bioanalytical Chemistry, 414(18), 5217-5237. (SCI)
  8. Chen, Z.Z., Wang, W.C., Johnson, L., Dufresne, J., Bowden, P., Trahtemberg, U., DosSantos, C., Ho, H.Y., Ho, J.A., Hsu, C.C.R, Marshall, J.* (2021). The Plasma Proteome. Research Square, DOI: 10.21203/ 870255/v1.
  9. Jou, A. F.-J., Chou Y.-T., Willner, I.* and Ho, J.-A. A.* (2021). Imaging of Cancer Cells and Dictated Cytotoxicity Using AptamerGuided Hybridization Chain Reaction (HCR)-Generated GQuadruplex Chains. Angewandte Chemie International Edition, 60, 21673 –21678. (SCI)
  10. Chang, Y.F., Chou, Y.T., Cheng, C.Y., Hsu, J.F., Su, L.C.*, Ho, J.-a. A.* (2021). Amplification-free detection of cytomegalovirus miRNA using a modification-free surface plasmon resonance biosensor. Analytical Chemistry, 93(22), 8002-8009. (SCI)
  11. Kai-Hsin Chang, Wei-Chih Chao, Yu-Hsuan Yang, Cheng-Ham Wu, Zhi-Bin Li, Hung-Che Chen, Yi-Te Chou, Ja-an Annie Ho, Xin-Cheng Li, Yu-Chiang Peng, Yu-Chan Liao, Kuan-Miao Liu*, Chi-Min Chao*, and Pi-Tai Chou* (2021). Cyano Derivatives of 7-Aminoquinoline that are Highly Emissive in Water: Potential for Sensing Applications. Chemistry—A European Journal, 27, 8040–8047. (SCI) DOI:10.1002/chem.202100413.
  12. Chou, Y.T., Lin, C.Y., Wen, J.W., Hung, L.C., Chang, Y.F., Yang, C.M.*, Wu, L.C.*, Ho, J.-a. A.* (2021). Targeting triple negative breast cancer with an - aptamer functionalized nanoformulation: a synergistic treatment that combines - photodynamic and bioreductive therapies. Journal of Nanobiotechnology, 19, 89. (SCI) DOI: 10.1186/s12951-021-00786-8.
  13. Thiruppathi, M., Lee, J.F., Chen, C.C.*, Ho, J.-a. A.* (2021). A disposable electrochemical sensor designed to estimate glycated hemoglobin (HbA1c) level in whole blood. Sensors and Actuators B: Chemical, 329. (SCI) DOI: 10.1016/j.snb.2020.129119.
  14. Thiruppathi, M., Tsai, C.-Y, Wang, T.-W, Tsao, Y., Wu, T.-H, Ho, J.-a. A.* (2020). Simple and Cost-effective Enzymatic Detection of Cholesterol Using Flow Injection Analysis. Analytical Sciences, 36(9), 1119-1124. (SCI)
  15. Chang, Y.-F., Huang, Y.-Q., Wu, K.-M., Jou, A. F.-j., Shih, N.-Y.*, Ho, J.-a. A.* (2019). Diagnosing the RGS11 lung cancer biomarker: The integration of competitive immunoassay and isothermal nucleic acid exponential amplification reaction. Analytical Chemistry, 91(5), 3327-3335. (SCI)
  16. Murugan Thiruppathi, Pei-Ying Lin, Yi-Te Chou, Hsin-Yu Ho, Li-chen Wu, Ja- an Annie Ho* (2019). Simple aminophenol-based electrochemical probes for non-enzymatic, dual amperometric detection of NADH and hydrogen peroxide. Talanta, 200, 450–457. (SCI)


  1. Huang, S.-P., Ho, T.-M., Yang, C.-W., Chang, Y.-J., Chen, J.-F., Shaw, N.-S., Horng, J.-C., Hsu, S.-L., Liao, M.-Y., Wu, L.-C., Ho, J.-a. A.* (2017) Chemopreventive Potential of Ethanolic Extracts of Luobuma Leaves (Apocynum venetum L.) in Androgen Insensitive Prostate Cancer. Nutrients, 9, 948. (SCI) DOI:10.3390/nu9090948
  2. Jou, A. F.-J. and Chen, Y.-J., Li, Y., Chang, Y.-F., Lee, J.-J., Liao, A. T., Ho, J.-a. A.* (2017) Target-Triggered, Dual Amplification Strategy for Sensitive Electrochemical Detection of a Lymphoma-associated MicroRNA. Electrochimica Acta, 236, 190-197. (SCI) DOI:10.1016/j.bios.2015.10.012
  3. Li, M.-C. and Chang, Y.-F., Wang, H.-Y., Lin, Y.-X., Kuo, C.-C., Ho, Ja-an Annie*, Lee, C.-C., Su, L.-C. (2017) An innovative application of time-domain spectroscopy on localized surface plasmon resonance sensing. Scientific Reports, 7, 44555. (SCI) DOI: 10.1038/srep44555
  4. Li, Y., Hsieh, C.-H., Lai, C.-W., Chang, Y.-F., Chen, H.-Y., Tsai, C.-F., Ho, J. A., Wu, L.-C. (2017) Tyramine detection using PEDOT:PSS/AuNPs/1-methyl-4-mercaptopyridine modified screen-printed carbon electrode with molecularly imprinted polymer solid phase extraction. Biosensors and Bioelectronics, 87, 142-149. (SCI) DOI:10.1016/j.bios.2016.08.006
  1. Chang, Y.-F.; Fu, C.; Chen, Y.-T.; Chen, C.-C., Chou, C. and Ho, J.-a. A.* (2016) Use of liposomal amplifiers in total internal reflection fluorescence fiber-optic biosensors for protein detection. Biosensors and Bioelectronics, 77, 1201-1207. (SCI) DOI:10.1016/j.bios.2015.10.012
  1. Chang, H.-C. and Ho, J.-a. A.* (2015) Gold Nanocluster-Assisted Fluorescent Detection for Hydrogen Peroxide and Cholesterol Based on the Inner Filter Effect of Gold Nanoparticles. Analytical Chemistry, 87(20), 10362-10367. (SCI) DOI: 10.1021/acs.analchem.5b02452
  2. Lee, M.-t. G, Wang, H.-M., Ho, J.-a. A., Fan, N.-C., Yang, Y.-L.,  Lee, C.-C.*, Chen, S.-C. (2015) Resuscitation Using Liposomal Vasopressin in an Animal Model of Uncontrolled Hemorrhagic Shock. Plos One, 10(7), e0130655. (SCI) DOI: 10.1371/journal.pone.0130655
  3. Chang, Y.-J., Hsu, S.-L., Liu, Y.-T., Lin, Y.-H., Lin, M.-H., Huang, S.-J., Ho, J.-a. A.; Wu, L.-C.* (2015) Gallic Acid Induces Necroptosis via TNF-alpha Signaling Pathway in Activated Hepatic Stellate Cells. Plos One, 10(3), e0120713. (SCI) DOI: 10.1371/journal.pone.0120713
  4. Lu, H.-Y., Chang, Y.-J., Fan, N.-C., Wang, L.-S., Lai, N.-C., Yang, C.-M., Wu, L.-C., Ho, J.-a. A.* (2015) Synergism through combination of chemotherapy and oxidative stress-induced autophagy in A549 lung cancer cells using redox-responsive nanohybrids: A new strategy for cancer therapy. Biomaterials, 42, 30-41. (SCI) DOI: 10.1016/j.biomaterials.2014.11.029
  5. Jou, A. F.-j., Lu, C.-H., Ou, Y.-C., Wang, S.-S., Hsu, S.-L., Willner I* and Ho, J.-a. A.* (2015) Diagnosing the miR-141 prostate cancer biomarker using nucleic acid-functionalized CdSe/ZnS QDs and telomerase. Chemical Science, 6, 659-665. (SCI) DOI: 10.1039/C4SC02104E
  1. Chang, H.-C., Chang, Y.-F., Fan, N.-C. and Ho, J.-a. A. (2014) Facile Preparation of High-Quantum-Yield Gold Nanoclusters: Application to Probing Mercuric Ions and Biothiols. ACS Applied Materials & Interfaces, 6, 18824-18831. (SCI) DOI: 10.1021/am504546f
  2. Tanwar, S., Lu, H.-Y., Magi, E.*, Ho, J.-a. A.* (2014) A 2,4-dinitrophenylhydrazine/kojic acid derivative as a simple colorimetric probe for determination of cupric ions in water. Sensors and Actuators B: Chemical, 203, 204-208. (SCI) DOI: 10.1016/j.snb.2014.06.041 
  3. Lai, Y.-H., Lee, C.-C., King, C.-C., Chuang, M.-C.*, Ho, J.-a. A.* (2014) Exploitation of stem-loop DNA as a dual-input gene sensing platform: extension to subtyping of influenza A viruses. Chemical Science, 2014, 5, 4082-4090. (SCI) DOI: 10.1039/C4SC01289E
  4. Jou, A. F.-J., Tai, N.-H., Ho, J.-a. A.* (2014) Gold Nanobone/Carbon Nanotube Hybrids for the Efficient Nonenzymatic Detection of H2O2 and Glucose. Electroanalysis, 26, 1816-1823. (SCI) DOI: 10.1002/elan.201400140
  5. Chen, S.-H., Hsu, Y.-Pb, Lu, H.-Y., Ho, J.A.A.* (2014) Gold/Phospholipid nanoconstructs as label-free optical probes for evaluating phospholipase A2 activity. Biosensors and Bioelectronics, 52, 202-208. (SCI) DOI: 10.1016/j.bios.2013.08.017
  6. Liao, W.-C., Ho, J.-a. A.* (2014) Improved activity of immobilized antibody by paratope orientation controller: Probing paratope orientation by electrochemical strategy and surface plasmon resonance spectroscopy. Biosensors and Bioelectronics, 55, 32-38. (SCI) DOI: 10.1016/j.bios.2013.10.054
  1. Chuang, M.-C., Lai, H.-Y., Ho, J.-a. A.*, Chen, Y.-Y. (2013) Multifunctional microelectrode array (mMEA) chip for neural-electrical and neural-chemical interfaces: Characterization of comb interdigitated electrode towards dopamine detection. Biosensors and Bioelectronics, 41, 602–607. DOI: 10.1016/j.bios.2012.09.030
  2. Tien, C.-Y., Jou, A.F.-J., Fan, N.-C., Chuang, M.-C., Ho, J.-A.A.* (2013) Preparation of Liposomal Progesterone and Its Application on the Measurement of Progesterone Interpreted via Electrochemical and Colorimetric Sensing Platforms. Electroanalysis, 25(4), 1017–1022. DOI: 10.1002/elan.201200563
  3. Teng, I.-T., Chang, Y.-J., Wang, L.-S., Lu, H.-Y., Wu, L.-C., Yang, C.-M., Chiu, C.-C., Yang, C.-H., Hsu, S.-L., Ho, J.-a. A.* (2013) Phospholipid-functionalized mesoporous silica nanocarriers forselective photodynamic therapy of cancer. Biomaterials, 34, 7462-7470. DOI: 10.1016/j.biomaterials.2013.06.001
  4. Tanwar, S.,* Ho, J.-a. A., Magi, E. (2013) Green synthesis and characterization of novel gold nanocomposites for electrochemical sensing applications. Talanta, 117, 352-358. DOI:10.1016/j.talanta.2013.09.011
  5. Liao, W.-C., Chuang, M.-C., Ho, J.-a. A.* (2013) Electrochemical sensor for multiplex screening of genetically modified DNA: Identification of biotech crops by logic-based biomolecular analysis. Biosensors and Bioelectronics, 50, 414-420. DOI: 10.1016/j.bios.2013.06.044


  1. Ho, J.-a. A.*, Jou, A. F.J., Wu, L.C., Hsu, S.L. (2012) Development of an immunopredictor for the evaluation of the risk of cardiovascular diseases based on the level of soluble P-selectin. Methods, 56(2), 223-229. (SCI) DOI: 10.1016/j.ymeth.2011.10.014 
  2. Prasad, K. S., Chuang, M.C.,  Ho J.-a. A.* (2011) Synthesis, characterization, and electrochemical applications of carbon nanoparticles derived from castor oil soot. Talanta, 88(15), 445-449. (SCI) DOI:10.1016/j.talanta.2011.10.056 
  3. Ho, J.-a. A.*, Kuo, T.Y., Yu, W.G. (2012) Dual polarization interferometric and capillary electrophoretic analysis of supported lipid bilayer constructed on silica-based surface: Evaluation of its anti-protein adsorption effect. Analytica Chimica Acta, 714(10), 127-133. DOI: 10.1016/j.aca.2011.11.062
  4. Ho, J.-a. A.*, Chang, H.C., Su, W.T. (2012) DOPA-mediated reduction allows the facile synthesis of fluorescent gold nanoclusters for use as sensing probes for ferric Ions. Analytical Chemistry, 82(7), 3246-3253. (SCI) DOI: 10.1021/ac203362g
  5. Chuang, M.C. and Ho, J.-a. A.* (2012) Efficient electrocatalytic oxidation of water: minimization of catalyst loading by an electrostatic assembly of hydrous iridium oxide colloids. RSC Advances, 2, 4092-4096. (SCI) DOI: 10.1039/C2RA00895E
  6. Tanwar, S. Chuang, M.C., Prasad, K.S., Ho, J.-a. A.* (2012) Template-free Synthesis of Electroactive Au-Calix-PPY nanocomposite for Electrochemical Sensor Applications. Green Chemistry, 14, 799-808. (SCI) DOI: 10.1039/C2GC16232F
  7. Prasad, K.S., Fan, N.C., Wi, L.C., Chang, J.C., Wang, L.S., Hwang, K.C., Hwu, J.R., Horng, J.C., Lin, C.C., Ho, J.-a. A.* (2012) A Tunable Multicolor Photoluminescent Nanocarbon Prepared from Castor Oil Soot.  Journal of the Chinese Chemical Society, 59(6), 802–808. (SCI) DOI: 10.1002/jccs.201100626
  8. Fan, N. C., Cheng, F. Y., Ho, J. A.*, Yeh, C. S.* (2012) Photocontrolled Targeted Drug Delivery: Photocaged Biologically Active Folic Acid as a Light-Responsive Tumor-Targeting Molecule. Angew. Chem. Int. Ed., 51(35), 8806-8810. (SCI) DOI: 10.1002/anie.201203339
  9. Ho, J.-a. A.*, Fan, N.C., Jou, A. F.J., Wu, L.C., Sun, T.P., (2012) Monitoring the subcellular localization of doxorubicin in CHO-K1 using MEKC−LIF: Liposomal carrier for enhanced drug delivery. Talanta, 99(15), 683-688. (SCI) DOI: 10.1016/j.talanta.2012.06.077
  10. Freeman, R., Girsh, J., Jou, A. F.J., Ho, J.-a. A., Hug, T., Dernedde, J., Willner, I.*, (2012) Optical Aptasensors for the Analysis of the Vascular Endothelial Growth Factor (VEGF). Anal. Chem., 84(14), 6192–6198.(SCI) DOI: 10.1021/ac3011473
  11. Viswanathana, S.*, Ranib, C., Ho, J.-a. A, (2012) Electrochemical immunosensor for multiplexed detection of food-borne pathogens using nanocrystal bioconjugates and MWCNT screen-printed electrode. Talanta, 94(30), 315–319. (SCI) DOI: 10.1016/j.talanta.2012.03.049
  12. Wang, L.S., Chuang, M.C., Ho, J.-a. A.* (2012) Nanotheranostics – a review of recent publications. Int. J. Nanomedicine, 7, 4679-4695. (SCI) DOI: 10.2147/IJN.S33065


  1. Su, L.C., Chang, Y.F., Chou, C., Ho, J.-a. A., Li, Y.C., Chou, L.D., Lee, C.C. (2011). Binding kinetics of biomolecule interaction at ultralow concentrations based on gold nanoparticle enhancement. Analytical Chemistry, 83(9): 3290-6. (SCI) DOI: 10.1021/ac1028616
  2. Jeng, C.C., Cheng, S.H., Ho, J.-a. A., Huang, S. H.-Y., Chang, J. C., Tsai, P.J., Yang, C.S., Lo, L.W. (2011) Dynamic probing of nanoparticle stability in vivo: a liposomal model assessed using in situ microdialysis and optical imaging. Journal of Nanomaterials, v.2011, 932719. (SCI) DOI:10.1155/2011/932719


  1. Ho, J.-a. A.*, Wu, L.C., Chang, L.H., Hwang, K.C, Hwa, J.-R. R. (2010) Liposome-based immunoaffinity chromatographic assay for the quantitation of immunoglobulin E in human serum. Journal of Chromatography B, 878(2), 172-176. (SCI) DOI: 10.1016/j.jchromb.2009.07.037
  2. Chou, C., Ho, J.-a. A., Chen, C.-C., Ming-Yaw, Liu, W.C., Chang, Y.F., Fu, C., Chen, S.H., Kuo, T.Y. Metal-Enhanced Fluorescence. Geddes, Chris D. (Ed), (2010) Chap 8, John Wiley & Sons press. ISBN: 978-0-470-22838-8  (Book Chapter)

  3. Ho, J.-a. A.*, Chang, H.C., Shih, N.Y.,Wu, L.C., Chang, Y.F., Chen, C.C., Chou, C. (2010) Diagnostic Detection of Human Lung Cancer-Associated Antigen Using a Gold Nanoparticle-Based Electrochemical Immunosensor. Analytical Chemistry, 82 (14), 5944–5950. (SCI) DOI: 10.1021/ac1001959

  4. Wang, L.S., Wu, L.C.*, Lu, S.Y., Chang, L.L., Teng, I.T, Yang, C.M.*, Ho, J.-a. A.* (2010) Biofunctionalized Phospholipid-Capped Mesoporous Silica Nanoshuttles for Targeted Drug Delivery: Improved Water Suspensibility and Decreased Nonspecific Protein Binding. ACS Nano, 4(8), 4371-4379. (SCI) DOI: 10.1021/nn901376h

  5. Chang, I.P, Hwang, K.C., Ho, J.-a. A., Lin, C.C., Hwa, J.-R. R., Horng, J.C. (2010) Facile surface functionalization of nanodiamonds. Langmuir, 26(5), 3685-3689. (SCI) DOI: 10.1021/la903162v

  6. Ho, J.-a. A.*, Hsua, W.L., Liao, W.C., Chiua, J.K., Chen, M.L., Chang, H.C., Lin, C.C. (2010) Ultrasensitive electrochemical detection of biotin using electrically addressable site-oriented antibody immobilization approach via aminophenyl boronic acid. Biosensors and Bioelectronics, 26(3), 1021-1027 (SCI) DOI: 10.1016/j.bios.2010.08.048

  7. Lu, C.L., Prasad K.S., Wu, H.L., Ho, J.-a. A., Huang, Michael H.*, (2010) Au Nanocube-Directed Fabrication of Au−Pd Core−Shell Nanocrystals with Tetrahexahedral, Concave Octahedral, and Octahedral Structures and Their Electrocatalytic Activity.  Journal of American Chemical Society, 132 (41), 14546–14553 (SCI) DOI: 10.1021/ja105401p

  8. Sahabuddina, Sk,Chang T.C., Lin, C.C., Jan F.D., Hsiao, H.Y., Huang, K.T., Chen, J.H. , Horng, J.C.,  Ho, J.-a. A, Lin, C.C.* (2010) Synthesis of N-modified sTn analogs and evaluation of their immunogenicities by microarray-based immunoassay. Tetrahedron, 66(38), 7510-7519 (SCI) DOI:10.1016/j.tet.2010.07.050

  9. Wu L.C., Jou, A. F.J., Chen, S.H., Tien, C.Y., Cheng, C.F., Fan, N.C., Ho, J.-a. A.* (2010) Antioxidant, anti-inflammatory and anti-browning activities of hot water extracts of oriental herbal teas. Food & Function, 1, 200-208 DOI: 10.1039/C0FO00047G

  10. Sourisa, J.S., Lee, C.H., Cheng, S.H., Chen, C.T., Yang, C.S, Ho, J.-a. A., Mou, C.Y., Lo, L.W.*, (2010) Surface Charge-Mediated Rapid Hepatobiliary Excretion of Mesoporous Silica Nanoparticles. Biomaterials, 31(21), 554-5574. DOI: 10.1016/j.biomaterials.2010.03.048


  1. Ho, J.-a. A.*; Lin, Y.C.; Wang, L.S.; Hwang, K.C. and Chou, P.T. (2009). Carbon nanoparticle‐enhanced immunoelectrochemical detection for protein tumor marker with CdS biotracers. Analytical Chemistry, 81(4), 1340-1346. (SCI) DOI: 10.1021/ac801832h
  2. Liao, W. C., Ho, J.-a. A.* (2009). Attomole DNA electrochemical sensor for the detection of Escherichia coli O157Analytical Chemistry, 81(7), 2470-2476. (SCI) DOI: 10.1021/ac8020517
  3. Ho, J.-a A.*, Chiu, J.K., Hsu, W.L., Hong, J.C., Lin, C.C., Hwang, K.C. and Hwu, J.R. (2009). Gold-Nanostructured Immunosensor for the Electrochemical Sensing of Biotin Based on Liposomal Competitive Assay. Journal of Nanoscience and Nanotechnology, 9(4), 2324-2329. (SCI) DOI: 10.1166/jnn.2009.SE40
  4. Viswanathan, S., Rani, C., Vijay Anand, A., Ho, J.-a. A. (2009). Disposable electrochemical immunosensor for carcinoembryonic antigen using ferrocene liposomes and MWCNT screen-printed electrode. Biosensors and Bioelectronics, 24(7), 1984-1989. (SCI) DOI: 10.1016/j.bios.2008.10.006
  5. Wu, L.C.*; Chang, L.H.; Chen, S.H.; Fan, N.C.; Ho, J.-a. A.** (2009). Antioxidant activity and melanogenesis inhibitory effect of the acetonic extract of Osmanthus fragrans: A potential natural and functional food flavor additive. LWT - Food Science and Technology, 42(9), 1513-1519. (SCI) DOI:10.1016/j.lwt.2009.04.004
  6. Chien, H.T., Lee, C.K., Chiu, H.K., Hsu, K.C., Chen, C.C.,* Ho, J.‐a. A., Chou, C. (2009). The Comparison between the Graded Photonic Crystal Coupler and Various Coupler. Journal of Lightwave Technology, 27(14), 2570-2574. (SCI) DOI: 10.1109/JLT.2008.2012271
  7. Ho, J.-a. A.*, Hung, C.H.,Wu, L.C., Liao, M.Y. (2009). Folic acid-anchored PEGgylated phospholipid bioconjugate and its application in a liposomal immunodiagnostic assay for folic acid. Analytical Chemistry, 81(14), 5671-5677. (SCI) DOI: 10.1021/ac900402v
  8. Lin, P.C., Adak, A.K., Ueng. S.H., Huang, L.D., Huang, K.T., Ho, J.-a.A., Lin C.C. (2009) DAST-mediated regioselective anomeric group migration in sacchardies. Journal of Organic Chemistry, 74(11), 4041-4048. (SCI) DOI: 10.1021/jo900516r
  9. Hwu, J.R.*, Huang,  J.-T. J., Tsai, F.Y., Tsay, S.C., Hsu, M.H., Hwang, K.C., Horng, J.C., Ho, J.-a. A, Lin, C.C. (2009). Photochemical Activities of N-Nitroso Carboxamides and Sulfoximides and Their Application to DNA Cleavage, Chemistry - A European Journal, 15(35), 8742 - 8750 (SCI) DOI: 10.1002/chem.200802571


  1. Ho, J-a A.*, Zeng, S.C., Tseng, W.H., Lin, Y.J. and Chen, C.H. (2008). Liposome-Based Immunostrip for the Rapid Detection of Salmonella. Analytical and Bioanalytical Chemistry391(2), 479-485. (SCI) DOI: 10.1007/s00216-008-1875-5

  2. Hsin,Y.L., Lin, C.F., Liang, Y.C., Hwang, K.C., Horng, J.C., Ho, J-a A., Lin, C.C. and Hwu, J.R.(2008). Microwave Arcing Induced Formation and Growth Mechanisms of Core/Shell Metal/Carbon Nanoparticles in Organic Solutions. Advanced Functional Materials, 18(14), 2048-2056. (SCI) DOI: 10.1002/adfm.200701407

  3. Ho, J.-a A.* and Hung, C.H. (2008). Using Liposomal Fluorescent Biolabels To Develop an Immunoaffinity Chromatographic Biosensing System for Biotin. Analytical Chemistry, 80(16), 6405-6409. (SCI) DOI: 10.1021/ac800850w


  1. Wu, L.C. and Ho, J-a A. In Spirulina in Human Nutrition and Health, Gershwin, M.E. and Belay, A. (Eds) (2007). Chap 6 (p119-152), CRC Press, Boca Raton, FL, USA. (Book Chapter)

  2. Subramanian, V., Liao, W.C., Huang, C.C., Hsu, W.L. and Ho, J-a A.* (2007). Rapid Analysis of L-dopa in Urine Samples Using Gold Nanoelectrode Ensembles. Talanta74, 229-234. (SCI) DOI: 10.1016/j.talanta.2007.05.056

  3. Kim, B.Y., Swearingen, C.B., Ho, J-a A., Romanova, E.V., Bohn, P.W. and Sweedler, J.V. (2007). Direct Immobilization of Fab’ in Nanocapillaries for Manipulating Mass-Limited Samples. Journal of American Chemical Society, 129(24), 7620-7626. (SCI) DOI: 10.1021/ja070041w

  4. Ho, J-a A.*, Wu, L.C., Huang, M.R., Lin, Y.J., Baeumner, A.J. and Durst, R.A. (2007). Application of Ganglioside-sensitized Liposomes in a Flow-Injection Immunoanalytical System for the Determination of Cholera Toxin. Analytical Chemistry, 79(1), 246-250. (SCI) DOI: 10.1021/ac060889n

  5. Subramanian, V. and Ho, J-a A.* (2007). Dual Electrochemical Determination of Glucose and Insulin Using Enzyme and Ferrocene Microcapsules. Biosensors and Bioelectronics, 22(6), 1147-1153. (SCI) DOI: 10.1016/j.bios.2006.07.031

  6. Ho, J-a A.*, Wu, L.C, Fan, N.C., Lee, M.S., Kuo, H.Y. and Yang, C.S. (2007). Development of a Long-life Capillary Enzyme Bioreactor for the Determination of Blood Glucose. Talanta, 71, 391-396. (SCI) DOI: 10.1016/j.talanta.2006.04.023


  1. Subramanian, V., Wu, L.C., Huang, M.R. and Ho, J-a A.* (2006). Electrochemical Immunosensor for Cholera Toxin Using Liposomes and poly(3,4-ethylenedioxythiophene)- Coated Carbon Nanotubes. Analytical Chemistry, 78(4), 1115-1121. (SCI) DOI: 10.1021/ac051435d

  2. Ho, J-a A.*, Zeng, S.C., Huang, M.R. and Kuo, H.Y. (2006). Development of Liposomal Immunosensor for the Measurement of Insulin with Femtomole Detection. Analytica Chimica Acta, 556, 127-132. (SCI) DOI: 10.1016/j.aca.2005.08.074

  3. Wu, L.C.*, Hsu, H.W., Chen, Y.C., Chiu, C.C., Chang, C.W., Lin, Y.Y. and Ho, J-a A.* (2006). Antioxidant and Antiproliferative Activities of Red Pitaya. Food Chemistry, 95, 319-327. (SCI) DOI: 10.1016/j.foodchem.2005.01.002

  4. Ho, J-a A.*, Kuo, H.Y., Wang, Y.T. and Yang, C.S. (2006). Occurrence of Aristolochic Acids in Over-the-Counter Chinese Prepared Medicines. Asian Journal of Chemistry, 18(1)253-258. (SCI)


  1. Ho, J-a A.* and Huang, M.R. (2005). Application of Liposomal Bioluminescent Label in the Development of Flow Injection Immunoanalytical System. Analytical Chemistry, 77(11), 3431-3436. (SCI) DOI: 10.1021/ac0484474

  2. Wu, L.C., Ho, J-a A., Shieh, M.C. and Lu, I.W. (2005). Antioxidant and Antiproliferative Activities of Spirulina and Chlorella Water Extracts. Journal of Agricultural and Food Chemistry, 53(10), 4207-4212. (SCI) DOI: 10.1021/jf0479517


  1. Lo, L.W., Ho, J-a A, Chang, Y.H., Chang, C.H, Yang, C.S. (2004). Potential Usage of Liposome-encapulated Phosphor for in vivo Imaging of Tissue Oxygenation. Biomedical Engineering Applications, Basis and Communications. 16(4), 224-229. (EI)
  2. Ho, J-a A.,* Hsu, H.W. and Huang, M.R. (2004). Liposome-based Microcapillary Immunosensor for Detection of Escherichia coli O157:H7. Analytical Biochemistry. 330:342-349. (SCI) DOI: 10.1016/j.ab.2004.03.038


  1. Ho, J-a A.* and Hsu, H.W. (2003). Procedures for Preparing Escherichia coli O157:H7 Immunoliposome and Its Application in Liposome Immunoassay. Analytical Chemistry. 75:4330-4334. (SCI) DOI: 10.1021/ac0343580

  2. Wu, L.C., Chen, Y.C., Ho, J-a A. and Yang, C.S. (2003). Inhibitory Effect of Red Koji Extracts on Mushroom Tyrosinase. Journal of Agricultural and Food Chemistry. 51: 4240-4246. (SCI) DOI: 10.1021/jf034064f
  3. Ho, J-a A.* and Durst, R.A. (2003). Detection of Fumonisin B1: Comparison of Flow-injection Liposome Immunoanalysis with High-performance Liquid Chromatography. Analytical Biochemistry. 312:7-13. (SCI) DOI: 10.1016/S0003-2697(02)00393-7


  1. Ho, J-a A.* and Wauchope, R.D. (2002). A rapid strip liposome immunoassay for aflatoxin B1. Analytical Chemistry. 74:1493-1496. (SCI) DOI: 10.1021/ac010903q
  2. Ho, J-a A., Yang, C.S. and Tzeng, H.F. (2001). Overview of capillary electrochromatography. 化學. 59(3):399-408.
  3. Ho, J-a A.* and Durst, R.A. (2000). Preparation of reagents for the determination of fumonisin B1 by flow-injection immunoanalyis. Analytica Chimica Acta. 414:51-60. (SCI) DOI: 10.1016/S0003-2670(00)00782-0
  4. Ho, J-a A.* and Durst, R.A. (2000). Development of a flow-injection liposome immunoanalytical (FILIA) system for fumonisin B1. Analytica Chimica Acta. 414:61-69. (SCI) DOI: 10.1016/S0003-2670(00)00786-8